A DNA nanodevice boosts tumour immunity

A DNA nanodevice that selectively modulates the lysosomal protease activity in tumour-associated macrophages, increasing their antigen presentation ability, attenuates tumour growth in vivo.

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Bibliographische Detailangaben
Veröffentlicht in:	Nature nanotechnology 2021-12, Vol.16 (12), p.1306-1307
Hauptverfasser:	Li, Jiang, Fan, Chunhai
Format:	Artikel
Sprache:	eng
Schlagworte:	631/61/350 639/925/926 Antigen presentation Antigens Cancer Chemistry and Materials Science Dendritic cells Deoxyribonucleic acid DNA Humans Immunotherapy Laboratories Macrophages Materials Science Nanoparticles Nanotechnology Nanotechnology and Microengineering Nanotechnology devices Neoplasms - therapy News & Views news-and-views Tumors
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Beschreibung
Zusammenfassung:	A DNA nanodevice that selectively modulates the lysosomal protease activity in tumour-associated macrophages, increasing their antigen presentation ability, attenuates tumour growth in vivo.
ISSN:	1748-3387 1748-3395
DOI:	10.1038/s41565-021-01002-2