CRISPR meets caspase
Diverse CRISPR–Cas systems protect prokaryotes against invasive genetic elements like phages. A new study finds that evolution has fused a multi-subunit CRISPR complex into a single protein that cuts RNA and interacts with an ancillary caspase-like peptidase, which may trigger cell suicide.
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| Veröffentlicht in: | Nature microbiology 2021-12, Vol.6 (12), p.1481-1482 |
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| container_end_page | 1482 |
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| container_issue | 12 |
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| container_title | Nature microbiology |
| container_volume | 6 |
| creator | Hochstrasser, Megan L. Nuñez, James K. |
| description | Diverse CRISPR–Cas systems protect prokaryotes against invasive genetic elements like phages. A new study finds that evolution has fused a multi-subunit CRISPR complex into a single protein that cuts RNA and interacts with an ancillary caspase-like peptidase, which may trigger cell suicide. |
| doi_str_mv | 10.1038/s41564-021-01001-y |
| format | Article |
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| ispartof | Nature microbiology, 2021-12, Vol.6 (12), p.1481-1482 |
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| language | eng |
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| source | MEDLINE; SpringerLink Journals |
| subjects | 631/326/41/2533 631/326/432 Biomedical and Life Sciences Caspase Caspases - genetics Clustered Regularly Interspaced Short Palindromic Repeats - genetics CRISPR CRISPR-Cas Systems Gene Editing Infectious Diseases Life Sciences Medical Microbiology Microbiology News & Views news-and-views Parasitology Peptidase Phages Prokaryotes Virology |
| title | CRISPR meets caspase |
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