CRISPR meets caspase

Diverse CRISPR–Cas systems protect prokaryotes against invasive genetic elements like phages. A new study finds that evolution has fused a multi-subunit CRISPR complex into a single protein that cuts RNA and interacts with an ancillary caspase-like peptidase, which may trigger cell suicide.

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Bibliographische Detailangaben
Veröffentlicht in:	Nature microbiology 2021-12, Vol.6 (12), p.1481-1482
Hauptverfasser:	Hochstrasser, Megan L., Nuñez, James K.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/326/41/2533 631/326/432 Biomedical and Life Sciences Caspase Caspases - genetics Clustered Regularly Interspaced Short Palindromic Repeats - genetics CRISPR CRISPR-Cas Systems Gene Editing Infectious Diseases Life Sciences Medical Microbiology Microbiology News & Views news-and-views Parasitology Peptidase Phages Prokaryotes Virology
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Beschreibung
Zusammenfassung:	Diverse CRISPR–Cas systems protect prokaryotes against invasive genetic elements like phages. A new study finds that evolution has fused a multi-subunit CRISPR complex into a single protein that cuts RNA and interacts with an ancillary caspase-like peptidase, which may trigger cell suicide.
ISSN:	2058-5276 2058-5276
DOI:	10.1038/s41564-021-01001-y