Molecular profiling of intrabony defects' gingival crevicular fluid

Aim To profile, for the first time, the gingival crevicular fluid (GCF) of intrabony defects against a wide array of inflammatory and regenerative markers. Materials and methods Twenty‐one patients contributed one intrabony defect and one periodontally healthy site. Clinical and radiographic measures were obtained. GCF samples were analyzed with multiplex bead immunoassays over 27 markers previously identified by our group. Comparisons were performed using Wilcoxon matched‐pairs signed‐ranks tests, using a Bonferroni corrected α = 0.05/27 = 0.0019. Results Intrabony defect sites presented significantly increased GCF volume and disease‐associated clinical and radiographic characteristics (p