Effects of common environmental endocrine-disrupting chemicals on zebrafish behavior

•Zebrafish behavior and its detection methods have been systematically integrated.•The neurotoxicity of EDCs to zebrafish was systematically analyzed and summarized.•EDCs disturb zebrafish behavior by inducing oxidative stress and AChE and DA damage.•The neurotoxicity of EDCs to larval zebrafish mainly showed in locomotor behavior. Environmental endocrine-disrupting chemicals (EDCs), a type of exogenous organic pollutants, are ubiquitous in natural aquatic environments. Therefor, this review focused on the use of the zebrafish as a model to explore the effect of different EDCs on behavior, as well as the molecular mechanisms that drive these effects. Furthermore, our study summarizes the current knowledge on the neuromodulatory effects of different EDCs in zebrafish. This study also reviews the current state of zebrafish behavior research, in addition to the potential mechanisms of single and mixed pollutant-driven behavioral dysregulation at the molecular level, as well as the applications of zebrafish behavior experiments for neuroscience research. This review broadens our understanding of the influence of EDCs on zebrafish behavior and provides guidance for future research. [Display omitted]