Bothrops jararacussu snake venom lectin induces mast cell activation and vascular permeability enhance in an animal model

Bothrops species trigger an acute inflammatory response in victims, with activated leukocytes releasing several mediators that may contribute to local and systemic effects. The effects of BjcuL, a lectin isolated from B. jararacussu snake venom, on mast cells and vasopermeability were investigated in this study. BjcuL activates mast cells and increases vasopermeability through the involvement of histamine and platelet activating factor, which may play a role in the victims' acute inflammatory reaction. •BjcuL activates mast cells.•BjcuL increases vasopermeability.•BjcuL-induced vasopermeability was mediated by histamine and platelet-activating factor.