Hydroxocobalamin rescue from nimodipine-induced refractory vasoplegia

Hydroxocobalamin rescue from nimodipine-induced refractory vasoplegia

•Refractory vasoplegia is a rare but life-threatening adverse reaction to nimodipine therapy.•This case demonstrated the effective and safe reversal of nimodipine-induced refractory vasoplegia with hydroxocobalamin.•Early recognition of nimodipine-induced refractory vasoplegia is essential to improv...

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Veröffentlicht in:Clinical neurology and neurosurgery 2021-12, Vol.211, p.107026-107026, Article 107026
Hauptverfasser: Cooper, Thomas M., Shewmaker, Justin W., Blunck, Joseph R.
Format: Artikel
Sprache:eng
Schlagworte:
Anesthesia
Aneurysms
Angiotensin
Angiotensin-converting enzyme inhibitors
Arterial lines
Blood pressure
Catecholamines
Cyclic GMP
Cytokines
Diuretics
Drug dosages
Embolization
FDA approval
Heart
Heart attacks
Heart surgery
Hospitals
Hydroxocobalamin
Hypertension
Hypotension
Inflammation
Myocardial infarction
Neurology
Nimodipine
Nitric oxide
Nitric-oxide synthase
Peptidyl-dipeptidase A
Renal failure
Vasoactive agents
Vasodilation
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Beschreibung
Zusammenfassung:•Refractory vasoplegia is a rare but life-threatening adverse reaction to nimodipine therapy.•This case demonstrated the effective and safe reversal of nimodipine-induced refractory vasoplegia with hydroxocobalamin.•Early recognition of nimodipine-induced refractory vasoplegia is essential to improve hemodynamic stability with appropriate rescue therapy.
ISSN:0303-8467
1872-6968
DOI:10.1016/j.clineuro.2021.107026