Distinct Characteristics Between Perivascular and Subcutaneous Adipose-Derived Stem Cells

Adipose-derived stem cells (ADSCs) can differentiate into vascular lineages and participate in vascular remodeling. Perivascular ADSCs (PV-ADSCs) draw attention because of their unique location. The heterogeneity of subcutaneous (SUB) and abdominal ADSCs were well addressed, but PV-ADSCs' heter...

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Veröffentlicht in:	Diabetes (New York, N.Y.) N.Y.), 2022-02, Vol.71 (2), p.321-328
Hauptverfasser:	Xie, Yao, Ji, Yongli, Lu, Yunrui, Ma, Yuankun, Ni, Hui, Shen, Jian, Ma, Hong, Jin, Chunna, Chen, Yuwen, Lin, Yan, Xiang, Meixiang
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blood Vessels - cytology Cell Differentiation Cell Proliferation Cells, Cultured Estrone sulfotransferase Intercellular adhesion molecule 1 Mice Mice, Inbred C57BL Myocytes, Smooth Muscle - physiology Phenotypes Single-Cell Analysis Smooth muscle Stem cells Stem Cells - cytology Stem Cells - physiology Subcutaneous Fat - cytology
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Zusammenfassung:	Adipose-derived stem cells (ADSCs) can differentiate into vascular lineages and participate in vascular remodeling. Perivascular ADSCs (PV-ADSCs) draw attention because of their unique location. The heterogeneity of subcutaneous (SUB) and abdominal ADSCs were well addressed, but PV-ADSCs' heterogeneity has not been investigated. In this study, we applied single-cell analysis to compare SUB-ADSCs and PV-ADSCs regarding their subpopulations, functions, and cell fates. We uncovered four subpopulations of PV-ADSCs (Dpp4+, Col4a2+/Icam1+, Clec11a+/Cpe+, and Sult1e1+ cells), among which the Clec11a+ subpopulation potentially participated in and regulated PV-ADSC differentiation toward a smooth muscle cell (SMC) phenotype. Distinct characteristics between PV-ADSCs and SUB-ADSCs were revealed.
ISSN:	0012-1797 1939-327X
DOI:	10.2337/db20-1129