Positive effects of amphiregulin on human oocyte maturation and its molecular drivers in patients with polycystic ovary syndrome

Positive effects of amphiregulin on human oocyte maturation and its molecular drivers in patients with polycystic ovary syndrome

Abstract STUDY QUESTION Does use of medium containing amphiregulin improve meiotic maturation efficiency in oocytes of women with polycystic ovary syndrome (PCOS) undergoing in vitro maturation (IVM) preceded by a capacitation culture step capacitation IVM (CAPA-IVM)? SUMMARY ANSWER Use of medium co...

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Veröffentlicht in:Human reproduction (Oxford) 2021-12, Vol.37 (1), p.30-43
Hauptverfasser: Akin, Nazli, Le, Anh H, Ha, Uyen D T, Romero, Sergio, Sanchez, Flor, Pham, Toan D, Nguyen, Minh H N, Anckaert, Ellen, Ho, Tuong M, Smitz, Johan, Vuong, Lan N
Format: Artikel
Sprache:eng
Schlagworte:
Amphiregulin - genetics
Amphiregulin - metabolism
Animals
Cohort Studies
Female
Humans
In Vitro Oocyte Maturation Techniques - methods
Oocytes - metabolism
Polycystic Ovary Syndrome - metabolism
Pregnancy
Prospective Studies
Protein Serine-Threonine Kinases
TRPM Cation Channels - metabolism
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Zusammenfassung:Abstract STUDY QUESTION Does use of medium containing amphiregulin improve meiotic maturation efficiency in oocytes of women with polycystic ovary syndrome (PCOS) undergoing in vitro maturation (IVM) preceded by a capacitation culture step capacitation IVM (CAPA-IVM)? SUMMARY ANSWER Use of medium containing amphiregulin significantly increased the maturation rate from oocytes retrieved from follicles with diameters
ISSN:0268-1161
1460-2350
DOI:10.1093/humrep/deab237