Characterization of myeloid neoplasms following allogeneic hematopoietic cell transplantation

We compared characteristics of myeloid neoplasms (MNs) following allogeneic hematopoietic cell transplantation (HCT) versus autologous HCT using a Japanese HCT registry database. Among 43 788 patients who underwent allogeneic (n = 18 874) or autologous HCT (n = 24 914) for non‐myeloid malignancies o...

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Veröffentlicht in:	American journal of hematology 2022-02, Vol.97 (2), p.185-193
Hauptverfasser:	Kuno, Masatomo, Yamasaki, Satoshi, Fujii, Nobuharu, Ishida, Yasushi, Fukuda, Takahiro, Kataoka, Keisuke, Uchida, Naoyuki, Katayama, Yuta, Sato, Maho, Onai, Daishi, Miyamoto, Toshihiro, Ota, Shuichi, Yoshioka, Satoshi, Ara, Takahide, Hangaishi, Akira, Hashii, Yoshiko, Onizuka, Makoto, Ichinohe, Tatsuo, Atsuta, Yoshiko, Inamoto, Yoshihiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Autografts Chromosome 5 Cord blood Female Hematology Hematopoietic Stem Cell Transplantation - adverse effects Humans Leukemia, Myeloid, Acute - etiology Male Middle Aged Multivariate analysis Myelodysplastic Syndromes - etiology Myeloproliferative Disorders - etiology Retrospective Studies Risk Factors Stem cell transplantation Transplantation Transplantation, Homologous - adverse effects Tumors
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Zusammenfassung:	We compared characteristics of myeloid neoplasms (MNs) following allogeneic hematopoietic cell transplantation (HCT) versus autologous HCT using a Japanese HCT registry database. Among 43 788 patients who underwent allogeneic (n = 18 874) or autologous HCT (n = 24 914) for non‐myeloid malignancies or non‐malignant diseases, 352 developed MNs. The cumulative incidence of MNs was lower after allogeneic HCT than after autologous HCT (0.3% vs. 1.8% at 10 years, respectively, p
ISSN:	0361-8609 1096-8652
DOI:	10.1002/ajh.26401