Metal-Specific Response of High-Resolution ICP-MS for Proteins Binding to Gold Nanoparticles in Human Serum
Metalloproteins have many different functions such as storage and transport of proteins, enzymes, signal transduction proteins, etc. Herein, for a selection of gold nanoparticles differing in shape, size, charge, and surface modification, the binding behavior in human serum was assessed with respect...
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| Veröffentlicht in: | Analytical chemistry (Washington) 2021-11, Vol.93 (45), p.14918-14922 |
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| container_title | Analytical chemistry (Washington) |
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| creator | Kuznetsova, Olga V Khlebtsov, Nikolai G Jarosz, Maciej Timerbaev, Andrei R |
| description | Metalloproteins have many different functions such as storage and transport of proteins, enzymes, signal transduction proteins, etc. Herein, for a selection of gold nanoparticles differing in shape, size, charge, and surface modification, the binding behavior in human serum was assessed with respect to metal-containing proteins. Our results based on sector-field ICP-MS measurements and a simple calculation algorithm indicate the possible involvement of proteins, incorporating Cu and Fe, in the formation of the biomolecular layer around the particle surface. Given that such binding encompasses a substantial amount of copper and iron within the serum proteome (>50%) at a calculated nanoparticle dose, it may result in depleting their biological functions and should be taken into account when selecting lead candidates with an improved biocompatibility. |
| doi_str_mv | 10.1021/acs.analchem.1c04236 |
| format | Article |
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| subjects | Algorithms Analytical chemistry Binding Biocompatibility Biological effects Chemistry Copper Gold Humans Iron Mass Spectrometry Mathematical analysis Metal Nanoparticles Metalloproteins Nanoparticles Protein transport Proteins Proteomes Signal transduction Spectrum Analysis Surface charge |
| title | Metal-Specific Response of High-Resolution ICP-MS for Proteins Binding to Gold Nanoparticles in Human Serum |
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