Brain responses to glucose ingestion are greater in children than adults and are associated with overweight and obesity

Objective This study investigated whether brain regions involved in the regulation of food intake respond differently to glucose ingestion in children and adults and the relationship between brain responses and weight status. Methods Data included 87 children (ages 7‐11 years) and 94 adults (ages 18‐35 years) from two cohorts. Healthy weight, overweight, and obesity were defined by Centers for Disease Control and Prevention criteria. Brain responses to glucose were determined by measuring cerebral blood flow using arterial spin labeling magnetic resonance imaging in brain regions involved in the regulation of eating behavior. Results Children showed significantly larger increases in brain responses to glucose than adults in the dorsal striatum (p < 0.01), insula (p < 0.01), hippocampus (p < 0.01), and dorsal‐lateral prefrontal cortex (p < 0.01). Responses to glucose in the dorsal striatum (odds ratio [OR] = 1.52, 95% CI 1.05‐2.20; p = 0.03), hippocampus (OR = 1.51, 95% CI: 1.02‐2.22; p = 0.04), insula (OR = 1.64, 95% CI: 1.11‐2.42; p = 0.01), and orbitofrontal cortex (OR = 1.63 95% CI: 1.12‐2.39; p = 0.01) were positively associated with overweight or obesity, independent of age group. Conclusions Children have greater brain responses to glucose ingestion than adults in regions involved in eating behavior, and these responses are associated with weight status.