Enantioselective β-C(sp 3 )-H arylation of amides via synergistic nickel and photoredox catalysis

Enantioselective β-C(sp 3 )-H arylation of amides via synergistic nickel and photoredox catalysis

An enantioselective benzylic β-C(sp )-H arylation of amides synergistic nickel and photoredox catalysis is reported. The C-H bond is activated by a bromine-radical-mediated C-H cleavage. This mild yet straightforward protocol provides arylation products in up to 96% yield and with up to 95% ee.

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Veröffentlicht in:Organic & biomolecular chemistry 2021-11, Vol.19 (43), p.9407-9409
Hauptverfasser: Zhang, Wu, Shu, Xiaomin, Huan, Leitao, Cheng, Buqing, Huo, Haohua
Format: Artikel
Sprache:eng
Schlagworte:
Amides
Bromine
Catalysis
Enantiomers
Hydrogen bonds
Nickel
Photoredox catalysis
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Zusammenfassung:An enantioselective benzylic β-C(sp )-H arylation of amides synergistic nickel and photoredox catalysis is reported. The C-H bond is activated by a bromine-radical-mediated C-H cleavage. This mild yet straightforward protocol provides arylation products in up to 96% yield and with up to 95% ee.
ISSN:1477-0520
1477-0539
DOI:10.1039/d1ob01774h