Comparison of the efficacy, safety and durability of a switch to co-formulated RPV/TDF-TAF/FTC or DTG/ABC/3TC in virologically-suppressed HIV-1-infected patients in a single Italian centre: a cohort data analysis

•There are multiple options for using three-drug single tablet regimens (STRs) in ART simplification strategies.•Switching strategies based on RPV/TDF-TAF/FTC (RPV-STR) and DTG/ABC/3TC (DTG-STR) regimens have never been compared.•Switching to DTG-STR or RPV-STR maintained virological suppression at 4 years.•A higher rate of discontinuation within 3 months was observed with DTG-STR.•Gastrointestinal disturbances were more frequent with DTG-STR. This study evaluated the efficacy, safety and durability of a switch to co-formulated RPV/TDF-TAF/FTC (RPV-STR) or DTG/ABC/3TC (DTG-STR) in virologically-suppressed HIV-positive patients in a single Italian centre. All HIV-infected ART-experienced patients switching to RPV-STR or DTG-STR with HIV-RNA