Serum Serotonin as a Biomarker of the Efficacy of PAP-Therapy in Sleep Apnea Syndrome

Serum Serotonin as a Biomarker of the Efficacy of PAP-Therapy in Sleep Apnea Syndrome

Serum serotonin levels were determined by HPLC in 30 patients with diagnosed obstructive sleep apnea syndrome before and after 3-month course of PAP-therapy and in 14 subjects without obstructive sleep apnea symptoms. It was found that elimination of hypoxic conditions was associated with an increas...

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Veröffentlicht in:Bulletin of experimental biology and medicine 2021-10, Vol.171 (6), p.713-715
Hauptverfasser: Madaeva, I. M., Berdina, O. N., Ukhinov, E. B., Kurashova, N. A., Semenova, N. V., Bairova, T. A., Bel’skikh, A. V., Natyaganova, L. V., Kolesnikov, S. I., Kolesnikova, L. I.
Format: Artikel
Sprache:eng
Schlagworte:
Apnea
Biomarkers
Biomarkers - blood
Biomedical and Life Sciences
Biomedicine
Case-Control Studies
Cell Biology
Continuous Positive Airway Pressure
Female
High-performance liquid chromatography
Humans
Hypoxia
Hypoxia - blood
Hypoxia - diagnosis
Hypoxia - physiopathology
Hypoxia - therapy
Internal Medicine
Laboratory Medicine
Male
Middle Aged
Neurophysiology
Pathology
Phenols
Polysomnography
Serotonin
Serotonin - blood
Sleep
Sleep - physiology
Sleep apnea
Sleep apnea syndromes
Sleep Apnea, Obstructive - blood
Sleep Apnea, Obstructive - diagnosis
Sleep Apnea, Obstructive - physiopathology
Sleep Apnea, Obstructive - therapy
Sleep disorders
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Zusammenfassung:Serum serotonin levels were determined by HPLC in 30 patients with diagnosed obstructive sleep apnea syndrome before and after 3-month course of PAP-therapy and in 14 subjects without obstructive sleep apnea symptoms. It was found that elimination of hypoxic conditions was associated with an increase in serotonin level. The results demonstrate the effectiveness of PAP-therapy during sleep and allow assessing the role of serotonin as a potential biomarker of intermittent hypoxia during sleep.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-021-05301-5