The statistical power of genome-wide association studies for threshold traits with different frequencies of causal variants

The statistical power of genome-wide association studies for threshold traits with different frequencies of causal variants

This study aimed to investigate the effects of incidence rate, heritability, and polygenic variance on the statistical power of genome-wide association studies (GWAS) for threshold traits. Different incidence rates of threshold trait (1, 3, 5, 10, 25, 40, 50, 60, 75 and 90%), heritability (10 and 25...

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Veröffentlicht in:Genetica 2022-02, Vol.150 (1), p.51-57
Hauptverfasser: Khanzadeh, Hassan, Ghavi Hossein-Zadeh, Navid, Ghovvati, Shahrokh
Format: Artikel
Sprache:eng
Schlagworte:
Animal Genetics and Genomics
Biomedical and Life Sciences
Evolutionary Biology
Genome-wide association studies
Genome-Wide Association Study - methods
Genomes
Heritability
Human Genetics
Life Sciences
Mathematical models
Microbial Genetics and Genomics
Multifactorial Inheritance
Original Paper
Phenotype
Plant Genetics and Genomics
Polygenic inheritance
Polymorphism, Single Nucleotide
Statistical analysis
Statistical power
Variance
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Zusammenfassung:This study aimed to investigate the effects of incidence rate, heritability, and polygenic variance on the statistical power of genome-wide association studies (GWAS) for threshold traits. Different incidence rates of threshold trait (1, 3, 5, 10, 25, 40, 50, 60, 75 and 90%), heritability (10 and 25%), and polygenic variance ratio (0 and 25%) were simulated separately for common (MAF ≥ 0.05), low-frequency (0.05 > MAF ≥ 0.01), and rare (MAF 
ISSN:0016-6707
1573-6857
DOI:10.1007/s10709-021-00140-8