Isolated central nervous system familial hemophagocytic lymphohistiocytosis (fHLH) presenting as a mimic of demyelination in children

Isolated central nervous system familial hemophagocytic lymphohistiocytosis (fHLH) presenting as a mimic of demyelination in children

Isolated central nervous system (CNS) presentations of haemophagocytic lymphohistiocytosis (HLH), traditionally a systemic inflammatory condition, have been reported in adults and children. We identified nine patients with a diagnosis of isolated CNS familial hemophagocytic lymphohistiocytosis (fHLH...

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Veröffentlicht in:Multiple sclerosis 2022-04, Vol.28 (4), p.669-675
Hauptverfasser: Parida, Amitav, Abdel-Mannan, Omar, Mankad, Kshitij, Foster, Katharine, Ramdas, Sithara, Ram, Dipak, Eleftheriou, Despina, Hemingway, Cheryl, Hacohen, Yael, Wassmer, Evangeline
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Central Nervous System
Child
Children
Demyelinating Diseases
Demyelination
Hematopoietic stem cells
Histiocytosis
Humans
Inflammation
Lymphatic diseases
Lymphocytosis
Lymphohistiocytosis, Hemophagocytic - diagnosis
Lymphohistiocytosis, Hemophagocytic - genetics
Lymphohistiocytosis, Hemophagocytic - therapy
Morbidity
Nervous system
Stem cell transplantation
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Zusammenfassung:Isolated central nervous system (CNS) presentations of haemophagocytic lymphohistiocytosis (HLH), traditionally a systemic inflammatory condition, have been reported in adults and children. We identified nine patients with a diagnosis of isolated CNS familial hemophagocytic lymphohistiocytosis (fHLH) with symptom onset
ISSN:1352-4585
1477-0970
DOI:10.1177/13524585211053565