Systemic and Local Cytokines Profile Determine Severity and Prognosis in Human Septic Arthritis

Septic arthritis (SA) is a medical emergency. The most common etiological agents are bacteria, which activate the local immune response coordinated by cytokines; however, little is known about the cytokine profile in human SA. To determine the association of local and systemic cytokine profiles with...

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Veröffentlicht in:Archives of medical research 2022-02, Vol.53 (2), p.170-178
Hauptverfasser: Gonzalez-Chapa, Jorge A., Peña-Martinez, Victor M., Vílchez-Cavazos, José F., Salinas-Carmona, Mario C., Rosas-Taraco, Adrian G.
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Sprache:eng
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Zusammenfassung:Septic arthritis (SA) is a medical emergency. The most common etiological agents are bacteria, which activate the local immune response coordinated by cytokines; however, little is known about the cytokine profile in human SA. To determine the association of local and systemic cytokine profiles with the severity and prognosis of patients with SA. Patients with clinical and laboratory diagnosed SA were enrolled as well as a control group. Serum and synovial fluid (SF) samples were obtained for determining cytokines and glucose levels; SF samples were used for histological analysis. Osteochondral damage and general health status and quality of life (SF-36) were evaluated during recruitment day. WOMAC osteoarthritis index score and SF-36 questionnaire were used a year after recruitment day as a follow up. A systemic and local proinflammatory cytokine profile was found in patients compared to the control group (p
ISSN:0188-4409
1873-5487
DOI:10.1016/j.arcmed.2021.10.004