Randomized, Blinded, Placebo-Controlled Trial of De Simone Formulation Probiotic During HIV-Associated Suboptimal CD4+ T Cell Recovery

To assess whether probiotic supplementation may reduce disease-linked systemic immune activation in people living with HIV with the immunologic nonresponder phenotype. Phase 2b, randomized, double-blind, placebo-controlled pilot trial. HIV-positive individuals with blood CD4+ T-cell counts

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Bibliographische Detailangaben
Veröffentlicht in:	Journal of acquired immune deficiency syndromes (1999) 2022-02, Vol.89 (2), p.199-207
Hauptverfasser:	Rousseau, Rodney K., Walmsley, Sharon L., Lee, Terry, Rosenes, Ron, Reinhard, Robert J., Malazogu, Fat, Benko, Erika, Huibner, Sanja, Kovacs, Colin M., Singer, Joel, Kim, Connie J., Kaul, Rupert
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens Antiretroviral agents Biomarkers Blood Canada CD38 antigen CD4 antigen CD4 Lymphocyte Count CD4-Positive T-Lymphocytes CD8 antigen Cell activation Clinical trials Confidence intervals Dietary supplements Histocompatibility antigen HLA HIV HIV Infections HLA-DR Antigens Human immunodeficiency virus Humans Immune reconstitution Inflammation Leukocytes Lymphocytes T Microorganisms Monitoring Patients Permeability Phenotypes Placebos Probiotics Probiotics - therapeutic use Statistical analysis Telemedicine Translocation
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Beschreibung
Zusammenfassung:	To assess whether probiotic supplementation may reduce disease-linked systemic immune activation in people living with HIV with the immunologic nonresponder phenotype. Phase 2b, randomized, double-blind, placebo-controlled pilot trial. HIV-positive individuals with blood CD4+ T-cell counts
ISSN:	1525-4135 1944-7884
DOI:	10.1097/QAI.0000000000002840