The Photocatalyst-Free Cross-Dehydrogenative Coupling Reaction Enabled by Visible-Light Direct Excitation of Substrate

The Photocatalyst-Free Cross-Dehydrogenative Coupling Reaction Enabled by Visible-Light Direct Excitation of Substrate

A new photocatalyst-free strategy for the cross-dehydrogenative C–C and C–P coupling reaction has been described. This protocol provides a concise method to synthesize various 1-substituted tetrahydroisoquinoline (THIQ) derivatives enabled by visible-light direct excitation of substrates without usi...

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Veröffentlicht in:Journal of organic chemistry 2021-11, Vol.86 (21), p.15743-15752
Hauptverfasser: Guo, Xuan, Shao, Bing-ru, Jiang, Wen-feng, Shi, Lei
Format: Artikel
Sprache:eng
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Zusammenfassung:A new photocatalyst-free strategy for the cross-dehydrogenative C–C and C–P coupling reaction has been described. This protocol provides a concise method to synthesize various 1-substituted tetrahydroisoquinoline (THIQ) derivatives enabled by visible-light direct excitation of substrates without using any photocatalyst. Moreover, a wide substrate scope demonstrated good synthetic versatility and practicality.
ISSN:0022-3263
1520-6904
DOI:10.1021/acs.joc.1c01775