Optimal delineation of the clinical target volume for thymomas in the post-resection setting: A multi-center study

•The optimal postoperative clinical target volume in thymomas is not well-defined yet.•Significant inter-specialty variability exists in volume delineation of thymomas.•Collaboration of a surgeon with a radiation oncologist could improve delineations.•Delineation of post-operative thymoma volumes sh...

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Veröffentlicht in:Radiotherapy and oncology 2021-12, Vol.165, p.8-13
Hauptverfasser: Marcuse, Florit, Peeters, Stephanie, Herman, Kato, Vaassen, Femke, van Elmpt, Wouter, Maat, Alexander P.W.M., Praag, John, Billiet, Charlotte, Van Schil, Paul, Lambrecht, Maarten, Van Raemdonck, Dirk, Cao, Kim, Grigoroiu, Madalina, Girard, Nicolas, Hochstenbag, Monique, Maessen, Jos, De Ruysscher, Dirk
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Sprache:eng
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Zusammenfassung:•The optimal postoperative clinical target volume in thymomas is not well-defined yet.•Significant inter-specialty variability exists in volume delineation of thymomas.•Collaboration of a surgeon with a radiation oncologist could improve delineations.•Delineation of post-operative thymoma volumes should be performed multidisciplinary. The definition of the clinical target volume (CTV) for post-operative radiotherapy (PORT) for thymoma is largely unexplored. The aim of this study was to analyze the difference in CTV delineation between radiation oncologists (RTO) and surgeons. This retrospective multi-center study enrolled 31 patients who underwent PORT for a thymoma from five hospitals. Three CTVs were delineated per patient: one CTV by the RTO, one CTV by the surgeon (blinded to the results of the RTO) and a joint CTV after collaboration. Volumes (cm3), Hausdorff distances (HD) and Dice similarity coefficients (DSC) were analyzed. RTO delineated significantly bigger CTVs than surgeons (mean: 93.9 ± 63.1, versus 57.9 ± 61.3 cm3, p = 0.003). Agreement was poor between RO and surgeons, with a low mean DSC (0.34 ± 0.21) and high mean HD of 4.5 (±2.2) cm. Collaborative delineation resulted in significantly smaller volumes compared to RTO (mean 57.1 ± 58.6 cm3, p 
ISSN:0167-8140
1879-0887
DOI:10.1016/j.radonc.2021.10.007