Parotid salivary sodium levels of Sjögren's syndrome patients suggest B-cell mediated epithelial sodium channel disruption

Patients with primary Sjögren's syndrome (SS) suffer widely from lack of saliva production. Here we investigate potential mechanisms underpinning changes in SS patient saliva composition. Sodium concentration was significantly higher in all saliva samples collected: unstimulated submandibular/s...

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Veröffentlicht in:	Clinical and Experimental Rheumatology 2021-11, Vol.39 Suppl 133 (6), p.30-38
Hauptverfasser:	Pringle, Sarah A, Berkhof, Bas, van Ginkel, Marthe, Liefers, Silvia, van der Vegt, Bert, Spijkervet, Frederik K L, Bootsma, Hendrika, Vissink, Arjan, Kroese, Frans G M
Format:	Artikel
Sprache:	eng
Schlagworte:	Epithelial Sodium Channels Humans Parotid Gland Saliva Sjogren's Syndrome Sodium
Online-Zugang:	Volltext
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Zusammenfassung:	Patients with primary Sjögren's syndrome (SS) suffer widely from lack of saliva production. Here we investigate potential mechanisms underpinning changes in SS patient saliva composition. Sodium concentration was significantly higher in all saliva samples collected: unstimulated submandibular/sublingual (SmSl) saliva (p
ISSN:	0392-856X 1593-098X
DOI:	10.55563/clinexprheumatol/h9hivf