High RSK4 expression constitutes a predictor of poor prognosis for patients with clear cell renal carcinoma
This research focuses on exploring RSK4 protein expression within Clear Cell Renal Cell Carcinoma (ccRCC), based on these investigations on level of expressions coupled with the relevance to clinicopathologic features and clinical outcomes. The expression of RSK4 in 48 ccRCC and 20 hydronephrosis sa...
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| Veröffentlicht in: | Pathology, research and practice research and practice, 2021-11, Vol.227, p.153642-153642, Article 153642 |
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| container_title | Pathology, research and practice |
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| creator | Ma, Jing Wang, Kaijing Chai, Jia Xu, Tianqi Wei, Jie Liu, Yixiong Wang, Yangang Xu, Junpeng Li, Mingyang Fan, Linni |
| description | This research focuses on exploring RSK4 protein expression within Clear Cell Renal Cell Carcinoma (ccRCC), based on these investigations on level of expressions coupled with the relevance to clinicopathologic features and clinical outcomes.
The expression of RSK4 in 48 ccRCC and 20 hydronephrosis samples were under the detection of immunohistochemistry; besides, its relevance to the combination of clinicopathologic features with prognosis was committed in virtue of statistical approaches.
The 48 ccRCC samples included 36 (75%, 36/48) positive for RSK4, while the positive rate in hydronephrosis samples were 5 (25%, 5/20). Statistical analysis showed that RSK4 in ccRCC samples express higher expression the hydronephrosis samples (P |
| doi_str_mv | 10.1016/j.prp.2021.153642 |
| format | Article |
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The expression of RSK4 in 48 ccRCC and 20 hydronephrosis samples were under the detection of immunohistochemistry; besides, its relevance to the combination of clinicopathologic features with prognosis was committed in virtue of statistical approaches.
The 48 ccRCC samples included 36 (75%, 36/48) positive for RSK4, while the positive rate in hydronephrosis samples were 5 (25%, 5/20). Statistical analysis showed that RSK4 in ccRCC samples express higher expression the hydronephrosis samples (P < 0.05). Furthermore, the expression of RSK4 in ccRCC samples weren't correlated with ages and genders (P > 0.05), while WHO/ISUP nucleolar grade harboured relevance to low survival rate (P = 0.018). Molecular researches demonstrated that over-expression of RSK4 was able to upgrade the proliferation capability of ccRCC cell lines.
According to the expression pattern and molecular systems featured RSK4 in ccRCCs, it performed the function of a latent independent prognostic factor performing the function of a newly built latent therapeutic aim oriented with the patients undergoing RCC. Moreover, the specific mechanism of action is expected to be revealed in the future research.</description><identifier>ISSN: 0344-0338</identifier><identifier>EISSN: 1618-0631</identifier><identifier>DOI: 10.1016/j.prp.2021.153642</identifier><identifier>PMID: 34649054</identifier><language>eng</language><publisher>Germany: Elsevier GmbH</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Animals ; Biomarkers, Tumor - genetics ; Biomarkers, Tumor - metabolism ; Carcinoma, Renal Cell - enzymology ; Carcinoma, Renal Cell - genetics ; Carcinoma, Renal Cell - pathology ; ccRCC ; Cell Line, Tumor ; Cell Proliferation ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Immunohistochemistry ; Kidney Neoplasms - enzymology ; Kidney Neoplasms - genetics ; Kidney Neoplasms - pathology ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Middle Aged ; Predictive Value of Tests ; Prognosis ; Proliferation ; Ribosomal Protein S6 Kinases, 90-kDa - genetics ; Ribosomal Protein S6 Kinases, 90-kDa - metabolism ; RSK4 ; Tumor Burden ; Tumorigenesis ; Up-Regulation</subject><ispartof>Pathology, research and practice, 2021-11, Vol.227, p.153642-153642, Article 153642</ispartof><rights>2021 Elsevier GmbH</rights><rights>Copyright © 2021 Elsevier GmbH. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c353t-676162ce6326a778c1e9169c0c3578058370274349b67c7fa80a0a4150713d7c3</citedby><cites>FETCH-LOGICAL-c353t-676162ce6326a778c1e9169c0c3578058370274349b67c7fa80a0a4150713d7c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0344033821003034$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34649054$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ma, Jing</creatorcontrib><creatorcontrib>Wang, Kaijing</creatorcontrib><creatorcontrib>Chai, Jia</creatorcontrib><creatorcontrib>Xu, Tianqi</creatorcontrib><creatorcontrib>Wei, Jie</creatorcontrib><creatorcontrib>Liu, Yixiong</creatorcontrib><creatorcontrib>Wang, Yangang</creatorcontrib><creatorcontrib>Xu, Junpeng</creatorcontrib><creatorcontrib>Li, Mingyang</creatorcontrib><creatorcontrib>Fan, Linni</creatorcontrib><title>High RSK4 expression constitutes a predictor of poor prognosis for patients with clear cell renal carcinoma</title><title>Pathology, research and practice</title><addtitle>Pathol Res Pract</addtitle><description>This research focuses on exploring RSK4 protein expression within Clear Cell Renal Cell Carcinoma (ccRCC), based on these investigations on level of expressions coupled with the relevance to clinicopathologic features and clinical outcomes.
The expression of RSK4 in 48 ccRCC and 20 hydronephrosis samples were under the detection of immunohistochemistry; besides, its relevance to the combination of clinicopathologic features with prognosis was committed in virtue of statistical approaches.
The 48 ccRCC samples included 36 (75%, 36/48) positive for RSK4, while the positive rate in hydronephrosis samples were 5 (25%, 5/20). Statistical analysis showed that RSK4 in ccRCC samples express higher expression the hydronephrosis samples (P < 0.05). Furthermore, the expression of RSK4 in ccRCC samples weren't correlated with ages and genders (P > 0.05), while WHO/ISUP nucleolar grade harboured relevance to low survival rate (P = 0.018). Molecular researches demonstrated that over-expression of RSK4 was able to upgrade the proliferation capability of ccRCC cell lines.
According to the expression pattern and molecular systems featured RSK4 in ccRCCs, it performed the function of a latent independent prognostic factor performing the function of a newly built latent therapeutic aim oriented with the patients undergoing RCC. Moreover, the specific mechanism of action is expected to be revealed in the future research.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Animals</subject><subject>Biomarkers, Tumor - genetics</subject><subject>Biomarkers, Tumor - metabolism</subject><subject>Carcinoma, Renal Cell - enzymology</subject><subject>Carcinoma, Renal Cell - genetics</subject><subject>Carcinoma, Renal Cell - pathology</subject><subject>ccRCC</subject><subject>Cell Line, Tumor</subject><subject>Cell Proliferation</subject><subject>Female</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Kidney Neoplasms - enzymology</subject><subject>Kidney Neoplasms - genetics</subject><subject>Kidney Neoplasms - pathology</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Mice, Nude</subject><subject>Middle Aged</subject><subject>Predictive Value of Tests</subject><subject>Prognosis</subject><subject>Proliferation</subject><subject>Ribosomal Protein S6 Kinases, 90-kDa - genetics</subject><subject>Ribosomal Protein S6 Kinases, 90-kDa - metabolism</subject><subject>RSK4</subject><subject>Tumor Burden</subject><subject>Tumorigenesis</subject><subject>Up-Regulation</subject><issn>0344-0338</issn><issn>1618-0631</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEFPHDEMhaOqVdnS_oBeqhx7ma2dZJIZcUKIlqpISEDPUch6INvZyZBkafn3zWqBIyfL9vPT88fYZ4QlAupv6-Wc5qUAgUtspVbiDVugxq4BLfEtW4BUqgEpuwP2Iec1ABhQ-J4dSKVVD61asD9n4faOX179Upz-zYlyDnHiPk65hLItlLnjdbwKvsTE48DnWOuc4u0Uc8h82HWuBJpK5n9DueN-JJe4p3HkiSY3cu-SD1PcuI_s3eDGTJ-e6iH7_f30-uSsOb_48fPk-LzxspWl0UajFp60FNoZ03mkHnXvoa5NB20nDQijpOpvtPFmcB04cApbMChXxstD9nXvW2PebykXuwl5F8hNFLfZirYTHfatElWKe6lPMedEg51T2Lj0aBHsjrFd18lsd4ztnnG9-fJkv73Z0Orl4hlqFRztBVSffAiUbPYVkK8UE_liVzG8Yv8fLLaL1A</recordid><startdate>202111</startdate><enddate>202111</enddate><creator>Ma, Jing</creator><creator>Wang, Kaijing</creator><creator>Chai, Jia</creator><creator>Xu, Tianqi</creator><creator>Wei, Jie</creator><creator>Liu, Yixiong</creator><creator>Wang, Yangang</creator><creator>Xu, Junpeng</creator><creator>Li, Mingyang</creator><creator>Fan, Linni</creator><general>Elsevier GmbH</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202111</creationdate><title>High RSK4 expression constitutes a predictor of poor prognosis for patients with clear cell renal carcinoma</title><author>Ma, Jing ; Wang, Kaijing ; Chai, Jia ; Xu, Tianqi ; Wei, Jie ; Liu, Yixiong ; Wang, Yangang ; Xu, Junpeng ; Li, Mingyang ; Fan, Linni</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c353t-676162ce6326a778c1e9169c0c3578058370274349b67c7fa80a0a4150713d7c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Animals</topic><topic>Biomarkers, Tumor - genetics</topic><topic>Biomarkers, Tumor - metabolism</topic><topic>Carcinoma, Renal Cell - enzymology</topic><topic>Carcinoma, Renal Cell - genetics</topic><topic>Carcinoma, Renal Cell - pathology</topic><topic>ccRCC</topic><topic>Cell Line, Tumor</topic><topic>Cell Proliferation</topic><topic>Female</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Kidney Neoplasms - enzymology</topic><topic>Kidney Neoplasms - genetics</topic><topic>Kidney Neoplasms - pathology</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Mice, Nude</topic><topic>Middle Aged</topic><topic>Predictive Value of Tests</topic><topic>Prognosis</topic><topic>Proliferation</topic><topic>Ribosomal Protein S6 Kinases, 90-kDa - genetics</topic><topic>Ribosomal Protein S6 Kinases, 90-kDa - metabolism</topic><topic>RSK4</topic><topic>Tumor Burden</topic><topic>Tumorigenesis</topic><topic>Up-Regulation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ma, Jing</creatorcontrib><creatorcontrib>Wang, Kaijing</creatorcontrib><creatorcontrib>Chai, Jia</creatorcontrib><creatorcontrib>Xu, Tianqi</creatorcontrib><creatorcontrib>Wei, Jie</creatorcontrib><creatorcontrib>Liu, Yixiong</creatorcontrib><creatorcontrib>Wang, Yangang</creatorcontrib><creatorcontrib>Xu, Junpeng</creatorcontrib><creatorcontrib>Li, Mingyang</creatorcontrib><creatorcontrib>Fan, Linni</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pathology, research and practice</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ma, Jing</au><au>Wang, Kaijing</au><au>Chai, Jia</au><au>Xu, Tianqi</au><au>Wei, Jie</au><au>Liu, Yixiong</au><au>Wang, Yangang</au><au>Xu, Junpeng</au><au>Li, Mingyang</au><au>Fan, Linni</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>High RSK4 expression constitutes a predictor of poor prognosis for patients with clear cell renal carcinoma</atitle><jtitle>Pathology, research and practice</jtitle><addtitle>Pathol Res Pract</addtitle><date>2021-11</date><risdate>2021</risdate><volume>227</volume><spage>153642</spage><epage>153642</epage><pages>153642-153642</pages><artnum>153642</artnum><issn>0344-0338</issn><eissn>1618-0631</eissn><abstract>This research focuses on exploring RSK4 protein expression within Clear Cell Renal Cell Carcinoma (ccRCC), based on these investigations on level of expressions coupled with the relevance to clinicopathologic features and clinical outcomes.
The expression of RSK4 in 48 ccRCC and 20 hydronephrosis samples were under the detection of immunohistochemistry; besides, its relevance to the combination of clinicopathologic features with prognosis was committed in virtue of statistical approaches.
The 48 ccRCC samples included 36 (75%, 36/48) positive for RSK4, while the positive rate in hydronephrosis samples were 5 (25%, 5/20). Statistical analysis showed that RSK4 in ccRCC samples express higher expression the hydronephrosis samples (P < 0.05). Furthermore, the expression of RSK4 in ccRCC samples weren't correlated with ages and genders (P > 0.05), while WHO/ISUP nucleolar grade harboured relevance to low survival rate (P = 0.018). Molecular researches demonstrated that over-expression of RSK4 was able to upgrade the proliferation capability of ccRCC cell lines.
According to the expression pattern and molecular systems featured RSK4 in ccRCCs, it performed the function of a latent independent prognostic factor performing the function of a newly built latent therapeutic aim oriented with the patients undergoing RCC. Moreover, the specific mechanism of action is expected to be revealed in the future research.</abstract><cop>Germany</cop><pub>Elsevier GmbH</pub><pmid>34649054</pmid><doi>10.1016/j.prp.2021.153642</doi><tpages>1</tpages></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Animals Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Carcinoma, Renal Cell - enzymology Carcinoma, Renal Cell - genetics Carcinoma, Renal Cell - pathology ccRCC Cell Line, Tumor Cell Proliferation Female Gene Expression Regulation, Neoplastic Humans Immunohistochemistry Kidney Neoplasms - enzymology Kidney Neoplasms - genetics Kidney Neoplasms - pathology Male Mice Mice, Inbred BALB C Mice, Nude Middle Aged Predictive Value of Tests Prognosis Proliferation Ribosomal Protein S6 Kinases, 90-kDa - genetics Ribosomal Protein S6 Kinases, 90-kDa - metabolism RSK4 Tumor Burden Tumorigenesis Up-Regulation |
| title | High RSK4 expression constitutes a predictor of poor prognosis for patients with clear cell renal carcinoma |
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