INO-4800 DNA vaccine induces neutralizing antibodies and T cell activity against global SARS-CoV-2 variants

INO-4800 DNA vaccine induces neutralizing antibodies and T cell activity against global SARS-CoV-2 variants

Global surveillance has identified emerging SARS-CoV-2 variants of concern (VOC) associated with broadened host specificity, pathogenicity, and immune evasion to vaccine-induced immunity. Here we compared humoral and cellular responses against SARS-CoV-2 VOC in subjects immunized with the DNA vaccin...

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Veröffentlicht in:npj vaccines 2021-10, Vol.6 (1), p.121-121, Article 121
Hauptverfasser: Andrade, Viviane M., Christensen-Quick, Aaron, Agnes, Joseph, Tur, Jared, Reed, Charles, Kalia, Richa, Marrero, Idania, Elwood, Dustin, Schultheis, Katherine, Purwar, Mansi, Reuschel, Emma, McMullan, Trevor, Pezzoli, Patrick, Kraynyak, Kim, Sylvester, Albert, Mammen, Mammen P., Tebas, Pablo, Joseph Kim, J., Weiner, David B., Smith, Trevor R. F., Ramos, Stephanie J., Humeau, Laurent M., Boyer, Jean D., Broderick, Kate E.
Format: Artikel
Sprache:eng
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631/250/255/2514
631/250/590/1991
631/61/51/1991
692/699/255/2514
Antibodies
Biomedical and Life Sciences
Biomedicine
Brief Communication
COVID-19
COVID-19 vaccines
Deoxyribonucleic acid
DNA
Immune system
Immunization
Immunology
Infectious Diseases
Life Sciences & Biomedicine
Medical Microbiology
Medicine, Research & Experimental
Pathogens
Public Health
Research & Experimental Medicine
Science & Technology
Severe acute respiratory syndrome coronavirus 2
Vaccine
Vaccines
Virology
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Zusammenfassung:Global surveillance has identified emerging SARS-CoV-2 variants of concern (VOC) associated with broadened host specificity, pathogenicity, and immune evasion to vaccine-induced immunity. Here we compared humoral and cellular responses against SARS-CoV-2 VOC in subjects immunized with the DNA vaccine, INO-4800. INO-4800 vaccination induced neutralizing antibodies against all variants tested, with reduced levels detected against B.1.351. IFNγ T cell responses were fully maintained against all variants tested.
ISSN:2059-0105
2059-0105
DOI:10.1038/s41541-021-00384-7