WNT5B in cellular signaling pathways

The Wnt signaling ligand WNT5B is implicated in various developmental pathways, both in normal and pathological physiology. Most of the research on WNT5B has been associated with expression analysis and disease states, leaving the signaling pathways underexplored. Here, we review the current understandings of WNT5B’s regulation of signal transduction, from receptors to downstream mediators and transcription factors. We also describe its roles in β-catenin-dependent and β-catenin-independent (Planar Cell Polarity and Wnt/Ca2+) Wnt signaling. •WNT5B signals through β-catenin-independent (Wnt/Ca2+ and Wnt/PCP) signaling.•WNT5B induces crosstalk between β-catenin-independent signaling and Wnt/β-catenin-dependent signaling.