Odorant metabolism of the olfactory cleft mucus in idiopathic olfactory impairment patients and healthy volunteers

Odorant metabolism of the olfactory cleft mucus in idiopathic olfactory impairment patients and healthy volunteers

Background It remains unclear whether the metabolic activity of nasal mucus in the olfactory and respiratory areas is different. Moreover, age‐ and olfaction‐related changes may affect metabolism. Methods Hexanal, octanal, and 2‐methylbutanal were selected for in vitro metabolism analysis and compar...

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Veröffentlicht in:International forum of allergy & rhinology 2022-03, Vol.12 (3), p.293-301
Hauptverfasser: Ijichi, Chiori, Wakabayashi, Hidehiko, Sugiyama, Shingo, Hayashi, Kazuhiro, Ihara, Yusuke, Nishijima, Hironobu, Touhara, Kazushige, Kondo, Kenji
Format: Artikel
Sprache:eng
Schlagworte:
Alcohols
Aldehydes
enzyme
Gas chromatography
Healthy Volunteers
Hexanal
Hexanol
Hexanols - metabolism
Humans
idiopathic olfactory impairment
Mass spectroscopy
Metabolism
Middle Aged
Mucus
Mucus - metabolism
NADPH-diaphorase
Octanol
Odorants - analysis
Olfaction
Olfaction Disorders - metabolism
olfactory cleft mucus
Smell
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Beschreibung
Zusammenfassung:Background It remains unclear whether the metabolic activity of nasal mucus in the olfactory and respiratory areas is different. Moreover, age‐ and olfaction‐related changes may affect metabolism. Methods Hexanal, octanal, and 2‐methylbutanal were selected for in vitro metabolism analysis and compared between the olfactory cleft and respiratory mucus of participants 
ISSN:2042-6976
2042-6984
DOI:10.1002/alr.22897