Midterm outcomes of aortic root surgery in patients with Marfan syndrome: A prospective, multicenter, comparative study
The objective of this study was to compare midterm outcomes of aortic valve-replacing root replacement (AVR) and aortic valve-sparing root replacement (AVS) operations in patients with Marfan syndrome. Patients who met strict Ghent diagnostic criteria for Marfan syndrome and who underwent either AVR...
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Veröffentlicht in: | The Journal of thoracic and cardiovascular surgery 2023-05, Vol.165 (5), p.1790-1799.e12 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | The objective of this study was to compare midterm outcomes of aortic valve-replacing root replacement (AVR) and aortic valve-sparing root replacement (AVS) operations in patients with Marfan syndrome.
Patients who met strict Ghent diagnostic criteria for Marfan syndrome and who underwent either AVR or AVS between March 1, 2005 and December 31, 2010 were enrolled in a 3-year follow-up prospective, multicenter, international registry study; the study was subsequently amended to include 20-year follow-up. Enrollees were followed clinically and echocardiographically.
Of the 316 patients enrolled, 77 underwent AVR and 239 underwent AVS; 214 gave reconsent for 20-year follow-up. The median clinical follow-up time for surviving patients was 64 months (interquartile range, 42-66 months). Survival rates for the AVR and AVS groups were similar at 88.2% ± 4.4% and 95.0% ± 1.5%, respectively (P = .1). Propensity score-adjusted competing risk modeling showed associations between AVS and higher cumulative incidences of major adverse valve-related events, valve-related morbidity, combined structural valve deterioration and nonstructural valve dysfunction, and aortic regurgitation ≥2+ (all P |
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ISSN: | 0022-5223 1097-685X 1097-685X |
DOI: | 10.1016/j.jtcvs.2021.08.064 |