Enhanced therapeutic efficacy of a novel self-micellizing nanoformulation-loading fisetin against acetaminophen-induced liver injury

To evaluate the feasibility of using dipotassium glycyrrhizinate (DG) as a nanocarrier-loading fisetin (FIT) with strengthened treatment efficacies against liver injury induced by acetaminophen overdose. DG–FIT was prepared, and its efficacy against liver injury induced by acetaminophen overdose was evaluated. DG–FIT was successfully fabricated with excellent physicochemical properties. DG–FIT could be easily dissolved in water to form a clear micelle solution with high FIT encapsulation efficiency. FIT in DG–FIT exhibited a dramatically improved aqueous solubility. DG–FIT improved intestinal permeation. Regarding efficacies, DG–FIT exhibited significant effect against acetaminophen overdose by suppressing oxidative stress and proinflammatory cytokines involved. DG–FIT formulation possibly represents a promising method for strengthening the efficacy of FIT against acetaminophen-induced liver injury.