Copper-catalyzed synthesis of 1-(2-benzofuryl)-N-heteroarenes from o -hydroxy- gem -(dibromovinyl)benzenes and N-heteroarenes
An efficient method for the synthesis of 1-(2-benzofuryl)-N-heteroarenes is developed from -hydroxy- -(dibromovinyl)benzenes and N-heteroarenes under copper-catalyzed tandem reaction conditions. This methodology displayed a broad substrate scope and high yields in the preparation of a variety of 1-(...
Gespeichert in:
Veröffentlicht in: | Organic & biomolecular chemistry 2021-10, Vol.19 (41), p.9076-9080 |
---|---|
Hauptverfasser: | , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
Zusammenfassung: | An efficient method for the synthesis of 1-(2-benzofuryl)-N-heteroarenes is developed from
-hydroxy-
-(dibromovinyl)benzenes and N-heteroarenes under copper-catalyzed tandem reaction conditions. This methodology displayed a broad substrate scope and high yields in the preparation of a variety of 1-(2-benzofuryl)-N-heteroarenes. Further, 1-(2-benzofuryl)-N-heteroarenes were also applied in the synthesis of polycyclic benzofuro-indolo-pyridine scaffolds under palladium-catalyzed dehydrogenative coupling conditions. Overall, the present tandem approach is general, synthetically advantageous and avoids air-sensitive reagents. |
---|---|
ISSN: | 1477-0520 1477-0539 |
DOI: | 10.1039/d1ob01765a |