Bioaccumulation and oxidative stress caused by aluminium nanoparticles and the integrated biomarker responses in the common carp (Cyprinus carpio)

The use of nanoparticles (NPs) in various industries has experienced significant growth due to the advantages they offer, so the increase in their use has generated the continuous discharge of these products in numerous water bodies, which can affect the organisms that inhabit them. Previous studies have shown that Al is capable of producing oxidative stress in aquatic organisms; however, so far the impact of AlNP on hydrobionts is limited. Therefore, the objective of this work was to determine the oxidative stress produced by AlNP in liver, gill and blood of Cyprinus carpio, as well as their bioconcentration factor (BCF) in various tissues. For this purpose, the organisms were exposed to 50 μg L−1 AlNP for 12–96 h. Subsequently, the tissues were obtained and the activity of antioxidant enzymes, oxidative damage to lipids and proteins were determined, and the BCF was calculated for liver, brain, gill and muscle. The results showed alterations in the activity of antioxidant enzymes and increased levels of lipoperoxidation, hydroperoxides and oxidized proteins. When establishing the integrated biomarker response, it was observed that the liver is the most affected organ and these effects are related to the Al content in the tissue. Finally, it was observed that muscle and gills presented a higher BCF, compared to brain and liver. These findings show that AlNP are capable of generating oxidative stress in carp, affecting tissue function and accumulating, which represents an important risk for the health of fish such as common carp. [Display omitted] •The AlNPs are one of the most widely used nanoparticles in the world.•Exposure to 50 μg L−1 of AlNPs causes significant oxidative damage in liver and gill of common carp.•The IBRv2 index revealed a high biological response caused by AlNP exposure in liver of C. carpio.•Muscle and gills have a higher bioconcentration factor compared to brain and liver.