Ganglion cell complex and macular thickness layers in primary open-angle glaucoma, pseudoexfoliation glaucoma and healthy eyes: A comparative study

•Glaucoma comprises a range of disease entities that result in irreversible optic neuropathy.•The ability of OCT to provide retinal mapping of separate layers is an important advantage.•Very limited report is available about (inner and outer) layers of macular area between POAG, PXG, and healthy eyes.•GCC thickness is not significantly different between POAG and PXG except FLV.•Significant reduction in GCC, total and inner retinal thickness was demonstrated in moderate to severe PXG compared to moderate to severe POAG.••The macular ganglion cell complex, and outer retinal thickness may have an ability to detect early glaucoma in POAG and PXG eyes. : To investigate the differences in the ganglion cell complex (GCC) and macular thickness measurements between primary open-angle glaucoma (POAG), pseudoexfoliation glaucoma (PXG), and healthy eyes with optical coherence tomography (OCT)optovue. :In this non-randomized comparative cross-sectional study, 43 healthy eyes, 68 POAG eyes, and 57 PXG eyes were included. Patients were matched for age and disease severity. OCT angiography images were obtained for automated measurement of the GCC and macular thickness layers (inner and outer). : All GCC parameters were significantly difference between healthy and glaucomatous eyes (mild, and moderate to severe disease).There were no significant differences in GCC parameters between POAG and PXG patients except focal loss volume (FLV) after adjustment. Moderate to severe PXG eyes exhibited significantly lower GCC, larger global loss volume (GLV) values, and FLV values when compared with mild PXG eyes (p