Relevance of NR1I2 variants on carbamazepine therapy in Mexican Mestizos with epilepsy at a tertiary-care hospital

We evaluated the potential influence of genetic ( , , , , , , , and ) and nongenetic factors on carbamazepine (CBZ) response, adverse drug reactions and CBZ plasma concentrations in 126 Mexican Mestizos (MM) with epilepsy. Patients were genotyped for 27 variants using TaqMan assays. CBZ response was associated with variants and lamotrigine cotreatment. CBZ-induced adverse drug reactions were related to antiepileptic polytherapy and rs2298771/rs3812718 haplotype. CBZ plasma concentrations were influenced by -rs2276707 and -rs3814058, and by phenytoin cotreatment. CBZ daily dose was also influenced by -rs3814055 and -rs1051740. Interindividual variability in CBZ treatment was partly explained by , and variants, as well as antiepileptic cotreatment in MM with epilepsy.