Borylative Cyclization of 1,6-Allenynes Driven by BCl3

Borylative Cyclization of 1,6-Allenynes Driven by BCl3

A metal-free intramolecular borylative cyclization of 1,6-allenynes driven by BCl3 was developed. This method provides a general and practical strategy to construct valuable pyrrolidines containing all-carbon quaternary centers or 3,5-dihydroazepine derivatives depending on the substituents of the a...

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Veröffentlicht in:Organic letters 2021-10, Vol.23 (20), p.8050-8055
Hauptverfasser: Yang, Chun-Hua, Sun, Xiangkun, Niu, Congcong, Zhang, Zhiwei, Liu, Mingzhu, Zheng, Fangjie, Jiang, Ling, Kong, Xiangtao, Yang, Zhantao
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container_end_page 8055
container_issue 20
container_start_page 8050
container_title Organic letters
container_volume 23
creator Yang, Chun-Hua
Sun, Xiangkun
Niu, Congcong
Zhang, Zhiwei
Liu, Mingzhu
Zheng, Fangjie
Jiang, Ling
Kong, Xiangtao
Yang, Zhantao
description A metal-free intramolecular borylative cyclization of 1,6-allenynes driven by BCl3 was developed. This method provides a general and practical strategy to construct valuable pyrrolidines containing all-carbon quaternary centers or 3,5-dihydroazepine derivatives depending on the substituents of the allene, with conjugative and sterically hindered phenyl groups favoring the latter.
doi_str_mv 10.1021/acs.orglett.1c03062
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title Borylative Cyclization of 1,6-Allenynes Driven by BCl3
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