Borylative Cyclization of 1,6-Allenynes Driven by BCl3

Borylative Cyclization of 1,6-Allenynes Driven by BCl3

A metal-free intramolecular borylative cyclization of 1,6-allenynes driven by BCl3 was developed. This method provides a general and practical strategy to construct valuable pyrrolidines containing all-carbon quaternary centers or 3,5-dihydroazepine derivatives depending on the substituents of the a...

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Veröffentlicht in:Organic letters 2021-10, Vol.23 (20), p.8050-8055
Hauptverfasser: Yang, Chun-Hua, Sun, Xiangkun, Niu, Congcong, Zhang, Zhiwei, Liu, Mingzhu, Zheng, Fangjie, Jiang, Ling, Kong, Xiangtao, Yang, Zhantao
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Sprache:eng
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Zusammenfassung:A metal-free intramolecular borylative cyclization of 1,6-allenynes driven by BCl3 was developed. This method provides a general and practical strategy to construct valuable pyrrolidines containing all-carbon quaternary centers or 3,5-dihydroazepine derivatives depending on the substituents of the allene, with conjugative and sterically hindered phenyl groups favoring the latter.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.1c03062