Sequential Diimination, Staudinger [2 + 2] Ketene–Imine Cycloaddition, and Ring-Closing Metathesis (RCM) Reactions: In Route to Bis(4-spiro-fused-β-lactams)-Based Macrocycles

Based on sequential organic transformations, that is, diimine formation, Staudinger [2 + 2] ketene–imine cycloaddition, and ring-closing metathesis (RCM) reactions, the synthesis with full structural identification including NMR and HRMS spectral data along with single X-ray diffraction analysis (fo...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Journal of organic chemistry 2021-11, Vol.86 (21), p.14777-14785
Hauptverfasser: Habib, Osama M, Mohamed, Asaad S, Ibrahim, Yehia A, Al-Awadi, Nouria A
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Based on sequential organic transformations, that is, diimine formation, Staudinger [2 + 2] ketene–imine cycloaddition, and ring-closing metathesis (RCM) reactions, the synthesis with full structural identification including NMR and HRMS spectral data along with single X-ray diffraction analysis (for anti 7b, anti 8b, syn 9a, and anti 9b) of the first syn/anti bis-4-spiro-β-lactams-based azacrown ethers (7a,b–9a,b) is reported.
ISSN:0022-3263
1520-6904
DOI:10.1021/acs.joc.1c01576