Viscoelastic Testing in Traumatic Brain Injury: Key Research Insights

•Viscoelastic testing provides a rapid, comprehensive assessment of clot formation and breakdown.•Applications in the management of traumatic brain injury (TBI) continue to be explored.•This review highlights four key studies investigating the use of viscoelastic testing in TBI.•Areas of potential clinical utility and questions for future research efforts are identified. The role of viscoelastic testing in the evaluation and management of traumatic brain injury (TBI) remains a subject of ongoing exploration. This review highlights four key publications that provide significant insights into this subject. Holcomb et al. provided early evidence of the relationship between thromboelastography (TEG) and conventional coagulation tests (CCTs). Later, Samuels et al. used TEG to identify a unique coagulopathy phenotype in TBI characterized by a notable absence of fibrinolytic abnormalities. Dixon et al. built upon these findings by exploring the application of TEG in the context of antifibrinolytic administration, noting a similar lack of effect on LY30. Finally, Guillotte et al. demonstrated the utility of TEG-PM in assessing platelet dysfunction in TBI. While these studies provide key early support for the utility of viscoelastic testing in the TBI, further exploration is needed to define evidence-based guidelines for clinical application.