Chemical and Genetic Diversity of Ligularia kanaitzensis in the Hengduan Mountains Area. Chemical Relationship with L. subspicata

Root chemicals and the sequences of the internal transcribed spacers (ITSs) were analyzed for 9 Ligularia kanaitzensis and 3 L. subspicata samples collected in northwestern Yunnan and southwestern Sichuan, China. Subspicatins A and C were isolated from two L. kanaitzensis samples. Introgression of g...

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Veröffentlicht in:Chemistry & biodiversity 2021-11, Vol.18 (11), p.e2100444-n/a
Hauptverfasser: Hanai, Ryo, Okamoto, Yasuko, Hashida, Takuya, Shiojiri, Kosuzu, Ohsaki, Ayumi, Saito, Yoshinori, Tori, Motoo, Gong, Xun, Kuroda, Chiaki
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Sprache:eng
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Zusammenfassung:Root chemicals and the sequences of the internal transcribed spacers (ITSs) were analyzed for 9 Ligularia kanaitzensis and 3 L. subspicata samples collected in northwestern Yunnan and southwestern Sichuan, China. Subspicatins A and C were isolated from two L. kanaitzensis samples. Introgression of genes responsible for these compounds from L. subspicata was suggested by their strong connection with L. subspicata/L. lamarum and the geographical proximity of the samples to L. subspicata. DNA analysis of a set of 27 L. kanaitzensis samples including those analyzed previously showed that they belong to two clades, designated A and B. Together with the presence/absence of furanoeremophilane, the 27 samples were sorted into three groups: clade A/furan, clade B/furan, and clade B/non‐furan. The ancestral plant presumably belonged to clade B/non‐furan, because furanoeremophilanes are biosynthesized from eremophilan‐8‐ones. 1β‐Angeloyloxyfukinone, a likely intermediate between fukinone and subspicatin C, was isolated for the first time. This finding allowed us to propose plausible biosynthetic pathways of subspicatins A and C.
ISSN:1612-1872
1612-1880
DOI:10.1002/cbdv.202100444