Contribution of aged polystyrene microplastics to the bioaccumulation of pharmaceuticals in marine organisms using experimental and model analysis

Microplastics (MPs) in the environment would undergo extensive weathering, which can act as a vector affecting the accumulation of pollutants in organisms. However, the risk of organic pollutants adsorbed on aged MPs to marine organisms is poorly understood. This study revealed the contribution of aged polystyrene (PS) MPs to the total bioaccumulation of atorvastatin (ATV) and amlodipine (AML), and assessed the environmental risks via experimental and model analysis. The results showed that pharmaceuticals were more easily released in gastrointestinal fluids from aged MPs relative to that in simulated seawater. The hydrophobic pharmaceuticals were more bioaccessible than hydrophilic ones by organisms. Model analysis showed that ingestion of water and food were the most important uptake routes for pharmaceuticals in marine fish and seabirds, while aged PS MPs could decrease the bioaccumulation of pharmaceuticals (contributed for −2.9% and −1.2% for the total uptake of ATV, and −25.8% and −4.4% for AML), indicating the cleaning effect of aged MPs, and the potential higher exposure risks of pharmaceuticals in warm-blooded organisms than that in cold-blooded ones via ingested MPs. The study revealed the effect of aged MPs to the bioaccumulation of pharmaceuticals in marine organisms, and highlighted the combined risks of aged MPs and pharmaceuticals in the environment. [Display omitted] •Digestive fluids enhanced the release of pharmaceuticals from aged MPs in solution.•Hydrophobic pharmaceutical was more bioaccessible than hydrophilic ones by organism.•Aged polystyrene MPs decreased the bioaccumulation of pharmaceuticals in organism.•MP-sorbed pharmaceuticals showed higher risk to warm-blooded organism than cold-blooded ones.