Construction of C−C Axial Chirality via Asymmetric Carbene Insertion into Arene C−H Bonds

By using diazonaphthoquinones and anilines as key reagents and through a point‐to‐axis chiral transfer strategy, the atroposelective synthesis via asymmetric C(sp2)−H bond insertion reaction of arenes has been realized under rhodium catalysis, providing the resulting biaryl atropisomers in moderate to excellent yields with good enantiomeric ratios (up to 99:1). Further elaboration indicates this type of axially biaryl scaffold may have promising potentials in developing novel chiral ligands. By using diazonaphthoquinones and anilines as key reagents and through a point‐to‐axis chiral transfer strategy, the atroposelective synthesis via asymmetric C(sp2)−H bond insertion reaction of arenes has been realized under rhodium catalysis, providing the resulting biaryl atropisomers in moderate to excellent yields with good enantiomeric ratios (up to 99:1).