Biomarkers for prognosis in pancreatic neuroendocrine tumors

Pancreatic neuroendocrine tumors (PNETs) encompass a diverse group of malignancies marked by histological heterogeneity and highly variable clinical outcomes. We performed a systematic review on potential prognostic biomarkers in PNETs by searching the PubMed database. A total of 472 manuscripts wer...

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Veröffentlicht in:	Endocrine-related cancer 2021-12, Vol.28 (12), p.773-782
Hauptverfasser:	Zhu, Mojun, Sorenson, Karl R, Liu, Rebecca, Gould Rothberg, Bonnie E, Halfdanarson, Thorvardur R
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomarkers Biomarkers, Tumor Humans Medical prognosis Neuroectodermal Tumors, Primitive Neuroendocrine tumors Neuroendocrine Tumors - pathology Pancreas Pancreatic Neoplasms - pathology Prognosis Retrospective Studies Tumor markers
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Zusammenfassung:	Pancreatic neuroendocrine tumors (PNETs) encompass a diverse group of malignancies marked by histological heterogeneity and highly variable clinical outcomes. We performed a systematic review on potential prognostic biomarkers in PNETs by searching the PubMed database. A total of 472 manuscripts were reviewed in detail, of which 52 multivariate studies met the inclusion criteria proposed by the Reporting Recommendations for Tumor Marker Prognostic Studies. These altogether analyzed 53 unique targets, and 36 of them were statistically associated with survival.
ISSN:	1351-0088 1479-6821
DOI:	10.1530/ERC-21-0075