MFN2 Stabilization: A Bridge for Endoplasmic Reticulum Stress Sensitivity in Melanoma

MFN2 Stabilization: A Bridge for Endoplasmic Reticulum Stress Sensitivity in Melanoma

In a new article in the Journal of Investigative Dermatology, Wang et al. (2021) report that mitochondrial quality control modulates responses to endoplasmic reticulum (ER) stress in melanoma. They implicate a linear pathway of XBP1, MARCH5, and MFN2 that act together to regulate mitochondrial fissi...

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Veröffentlicht in:Journal of investigative dermatology 2021-12, Vol.141 (12), p.2782-2784
Hauptverfasser: Adelmann, Charles H., Rachmin, Inbal, Fisher, David E.
Format: Artikel
Sprache:eng
Schlagworte:
Endoplasmic Reticulum - metabolism
Endoplasmic Reticulum Stress
GTP Phosphohydrolases - genetics
GTP Phosphohydrolases - metabolism
Humans
Melanoma - metabolism
Mitochondria
Mitochondrial Proteins - metabolism
Mitophagy
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Zusammenfassung:In a new article in the Journal of Investigative Dermatology, Wang et al. (2021) report that mitochondrial quality control modulates responses to endoplasmic reticulum (ER) stress in melanoma. They implicate a linear pathway of XBP1, MARCH5, and MFN2 that act together to regulate mitochondrial fission and mitophagy and ultimately mediate melanoma cell sensitivity to ER stress. This work informs therapeutic combinations and biomarker strategies for targeting melanoma organellar homeostasis as well as for life‒death decisions.
ISSN:0022-202X
1523-1747
DOI:10.1016/j.jid.2021.05.003