Revisiting Diagnostic performances of serum erythropoïetin level and JAK2 mutation for polycythemias: analysis of a cohort of 1090 patients with red cell mass measurement

Summary We assessed the diagnostic performances of erythropoietin and JAK2 mutations in 1,090 patients with suspected polycythemia who were referred for red cell mass (RCM) measurement. In patients with a high haematocrit and/or haemoglobin level, a low erythropoietin level (=125%), 92·1% and 90% re...

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Veröffentlicht in:	British journal of haematology 2022-02, Vol.196 (3), p.676-680
Hauptverfasser:	Maslah, Nabih, Ravdan, Odonchimeg, Drevon, Louis, Verger, Emmanuelle, Belkhodja, Célia, Chomienne, Christine, Cassinat, Bruno, Kiladjian, Jean‐Jacques, Giraudier, Stéphane, Schlageter, Marie‐Hélène
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Amino Acid Substitution Clinical Decision-Making Disease Management Erythrocyte Indices Erythrocyte Volume Erythropoietin Erythropoietin - blood Gene Frequency Genetic Association Studies Genetic Predisposition to Disease Hematocrit Hematology Hemoglobin Humans JAK2 Janus kinase 2 Janus Kinase 2 - genetics Mutation myeloproliferative neoplasms (MPN) Plasma Volume Polycythemia Polycythemia vera Polycythemia Vera - blood Polycythemia Vera - diagnosis Polycythemia Vera - epidemiology Polycythemia Vera - genetics red cell mass Sensitivity and Specificity
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Zusammenfassung:	Summary We assessed the diagnostic performances of erythropoietin and JAK2 mutations in 1,090 patients with suspected polycythemia who were referred for red cell mass (RCM) measurement. In patients with a high haematocrit and/or haemoglobin level, a low erythropoietin level (=125%), 92·1% and 90% respectively. A very‐low erythropoietin level (
ISSN:	0007-1048 1365-2141
DOI:	10.1111/bjh.17848