Enhanced 13C NMR detects extended reaction networks in living cells

Enhanced 13C NMR detects extended reaction networks in living cells

Insights into intracellular chemistry have remained sparse, but would be impactful for the advancement of biomedicine and bioproduction. A suitable 13C NMR approach provides improvements in sensitivity that make extended reaction networks and assay time windows, previously inaccessible cell densitie...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2021-10, Vol.57 (81), p.10572-10575
Hauptverfasser: Pernille Rose Jensen, Sannelli, Francesca, Ludvig Tving Stauning, Meier, Sebastian
Format: Artikel
Sprache:eng
Schlagworte:
Cells (biology)
NMR
Nuclear magnetic resonance
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Beschreibung
Zusammenfassung:Insights into intracellular chemistry have remained sparse, but would be impactful for the advancement of biomedicine and bioproduction. A suitable 13C NMR approach provides improvements in sensitivity that make extended reaction networks and assay time windows, previously inaccessible cell densities and relative flux measurements accessible in living cells.
ISSN:1359-7345
1364-548X
DOI:10.1039/d1cc03838a