Impact of vomiting on P2Y12 platelet inhibition in patients with ST-elevation myocardial infarction: A prespecified subanalysis of the ON-TIME 3 trial

Vomiting is associated with lower levels of ticagrelor concentration and higher platelet reactivity in the early hours of ST-elevation myocardial infarction. These results support reloading with a ticagrelor loading dose and/or treatment with intravenous platelet inhibitors when patients vomit.

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Bibliographische Detailangaben
Veröffentlicht in:	The American heart journal 2022-01, Vol.243, p.39-42
Hauptverfasser:	Tavenier, Anne  H., Hermanides, Renicus  S., Ottervanger, Jan  Paul, Belitser, Svetlana  V., Klungel, Olaf.  H., van ‘t Hof, Arnoud  W.J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesics Blood Platelets Fentanyl Heart attacks Humans Intravenous administration Medical imaging Myocardial infarction Narcotics Pain Patients Percutaneous Coronary Intervention - adverse effects Plasma Platelet Aggregation Inhibitors Platelet Function Tests Platelets Purinergic P2Y Receptor Antagonists ST Elevation Myocardial Infarction - complications ST Elevation Myocardial Infarction - drug therapy Ticagrelor - adverse effects Treatment Outcome Vomiting Vomiting - chemically induced Vomiting - drug therapy
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Beschreibung
Zusammenfassung:	Vomiting is associated with lower levels of ticagrelor concentration and higher platelet reactivity in the early hours of ST-elevation myocardial infarction. These results support reloading with a ticagrelor loading dose and/or treatment with intravenous platelet inhibitors when patients vomit.
ISSN:	0002-8703 1097-6744
DOI:	10.1016/j.ahj.2021.08.011