Endometrial thickness changes after progesterone administration do not affect the pregnancy outcomes of frozen-thawed euploid blastocyst transfer: a retrospective cohort study

To evaluate whether the change in endometrial thickness from progesterone administration day to transfer day is related to pregnancy outcomes in single frozen-thawed euploid blastocyst transfer cycles. Observational cohort study. Single reproductive medical center. All patients were transferred with...

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Veröffentlicht in:Fertility and sterility 2021-12, Vol.116 (6), p.1502-1512
Hauptverfasser: Jin, Ziqi, Shi, Hao, Lu, Manman, Bu, Zhiqin, Huo, Mingzhu, Zhang, Yile
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container_end_page 1512
container_issue 6
container_start_page 1502
container_title Fertility and sterility
container_volume 116
creator Jin, Ziqi
Shi, Hao
Lu, Manman
Bu, Zhiqin
Huo, Mingzhu
Zhang, Yile
description To evaluate whether the change in endometrial thickness from progesterone administration day to transfer day is related to pregnancy outcomes in single frozen-thawed euploid blastocyst transfer cycles. Observational cohort study. Single reproductive medical center. All patients were transferred with a single biopsied euploid blastocyst, and their endometrium was prepared with hormone replacement therapy (HRT). The endometrial thickness on the day of blastocyst transfer and progesterone administration was measured by transvaginal ultrasound, and the difference between them and the change ratio were calculated. Clinical pregnancy rates and live birth rates. Endometrial ultrasound images of 508 euploid blastocyst transfer cycles using HRT were evaluated by transvaginal ultrasound. Overall, pregnancy outcomes were comparable in different groups of endometrial thickness changes. The results of multiple logistic regression showed that the clinical pregnancy rate and live birth rate did not significantly increase with the increase in endometrial thickness change ratios (per 10%) in the fully adjusted model as a continuous variable. In the adjustment model as a categorical variable, there was no statistical difference in pregnancy outcomes among the groups with changes in endometrial thickness. Interaction analysis showed that after adjusting for confounders, there was no statistically significant interaction between the endometrial thickness change ratio and pregnancy outcomes in all subgroups. In the euploid blastocyst transfer cycle of preparing the endometrium with HRT, the endometrial thickness change ratio after progesterone administration was not related to pregnancy outcomes. Cambios en el grosor endometrial luego de la administración de progesterona no afecta los resultados de embarazo de la transferencia congelado-descongelado del blastocito euploide: un estudio de cohorte retrospectivo. Evaluar si el cambio en el grosor endometrial entre el día de administración de progesterona y el día de transferencia está relacionado con los resultados de embarazo de los ciclos de transferencia congelado-descongelado de blastocitos euploides únicos. estudio cohorte observacional. centro de medicina reproductiva único. Todas las pacientes fueron transferidas con un blastocito euploide biopsiado único, y su endometrio fue preparado con terapia de reemplazo hormonal (HRT). El grosor endometrial en el día de transferencia del blastocito y la administración de progesteron
doi_str_mv 10.1016/j.fertnstert.2021.08.008
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Observational cohort study. Single reproductive medical center. All patients were transferred with a single biopsied euploid blastocyst, and their endometrium was prepared with hormone replacement therapy (HRT). The endometrial thickness on the day of blastocyst transfer and progesterone administration was measured by transvaginal ultrasound, and the difference between them and the change ratio were calculated. Clinical pregnancy rates and live birth rates. Endometrial ultrasound images of 508 euploid blastocyst transfer cycles using HRT were evaluated by transvaginal ultrasound. Overall, pregnancy outcomes were comparable in different groups of endometrial thickness changes. The results of multiple logistic regression showed that the clinical pregnancy rate and live birth rate did not significantly increase with the increase in endometrial thickness change ratios (per 10%) in the fully adjusted model as a continuous variable. In the adjustment model as a categorical variable, there was no statistical difference in pregnancy outcomes among the groups with changes in endometrial thickness. Interaction analysis showed that after adjusting for confounders, there was no statistically significant interaction between the endometrial thickness change ratio and pregnancy outcomes in all subgroups. In the euploid blastocyst transfer cycle of preparing the endometrium with HRT, the endometrial thickness change ratio after progesterone administration was not related to pregnancy outcomes. Cambios en el grosor endometrial luego de la administración de progesterona no afecta los resultados de embarazo de la transferencia congelado-descongelado del blastocito euploide: un estudio de cohorte retrospectivo. Evaluar si el cambio en el grosor endometrial entre el día de administración de progesterona y el día de transferencia está relacionado con los resultados de embarazo de los ciclos de transferencia congelado-descongelado de blastocitos euploides únicos. estudio cohorte observacional. centro de medicina reproductiva único. Todas las pacientes fueron transferidas con un blastocito euploide biopsiado único, y su endometrio fue preparado con terapia de reemplazo hormonal (HRT). El grosor endometrial en el día de transferencia del blastocito y la administración de progesterona fueron medidos por ecografía transvaginal, y la diferencia entre ellos y la proporción de cambio fueron calculadas. índices de embarazo clínico y nacidos vivos. Imágenes de ecografía endometrial de 508 ciclos de transferencia de blastocito euploide usando HRT fueron evaluados por ecografía transvaginal. En general, los resultados de embarazo fueron comparables entre los diferentes grupos de cambio de grosor endometrial. Los resultados de la regresión múltiple logística demostraron que los índices de embarazo clínico y nacidos vivos no aumentaron significativamente con el aumento de la proporción de cambio del grosor endometrial (por 10%) en el modelo ajustado completo como una variable continua. En el modelo ajustado como una variable categórica, no hubo diferencias estadísticas en los resultados de embarazo entre los grupos de cambio de grosor endometrial. El análisis de interacción demostró que luego de ajustar por variables de confusión, no hubo interacción estadísticamente significativa entre la proporción de cambio de grosor endometrial y los resultados de embarazo entre todos los subgrupos. En los ciclos de transferencias de blastocitos euploides preparando el endometrio con HRT, la proporción de cambio del grosor endometrial luego de la administración de progesterona no fue relacionado con los resultados de embarazo.</description><identifier>ISSN: 0015-0282</identifier><identifier>EISSN: 1556-5653</identifier><identifier>DOI: 10.1016/j.fertnstert.2021.08.008</identifier><identifier>PMID: 34538461</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; Cohort Studies ; Cryopreservation - trends ; Embryo Transfer - trends ; Endometrial thickness change ratio ; Endometrium - diagnostic imaging ; Endometrium - drug effects ; euploid blastocyst transfer ; Female ; hormone replacement therapy ; Humans ; Organ Size - drug effects ; Pregnancy ; Pregnancy Outcome - epidemiology ; pregnancy outcomes ; Progesterone - administration &amp; dosage ; Retrospective Studies ; transvaginal ultrasound</subject><ispartof>Fertility and sterility, 2021-12, Vol.116 (6), p.1502-1512</ispartof><rights>2021 The Authors</rights><rights>Copyright © 2021 The Authors. 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Observational cohort study. Single reproductive medical center. All patients were transferred with a single biopsied euploid blastocyst, and their endometrium was prepared with hormone replacement therapy (HRT). The endometrial thickness on the day of blastocyst transfer and progesterone administration was measured by transvaginal ultrasound, and the difference between them and the change ratio were calculated. Clinical pregnancy rates and live birth rates. Endometrial ultrasound images of 508 euploid blastocyst transfer cycles using HRT were evaluated by transvaginal ultrasound. Overall, pregnancy outcomes were comparable in different groups of endometrial thickness changes. The results of multiple logistic regression showed that the clinical pregnancy rate and live birth rate did not significantly increase with the increase in endometrial thickness change ratios (per 10%) in the fully adjusted model as a continuous variable. In the adjustment model as a categorical variable, there was no statistical difference in pregnancy outcomes among the groups with changes in endometrial thickness. Interaction analysis showed that after adjusting for confounders, there was no statistically significant interaction between the endometrial thickness change ratio and pregnancy outcomes in all subgroups. In the euploid blastocyst transfer cycle of preparing the endometrium with HRT, the endometrial thickness change ratio after progesterone administration was not related to pregnancy outcomes. Cambios en el grosor endometrial luego de la administración de progesterona no afecta los resultados de embarazo de la transferencia congelado-descongelado del blastocito euploide: un estudio de cohorte retrospectivo. Evaluar si el cambio en el grosor endometrial entre el día de administración de progesterona y el día de transferencia está relacionado con los resultados de embarazo de los ciclos de transferencia congelado-descongelado de blastocitos euploides únicos. estudio cohorte observacional. centro de medicina reproductiva único. Todas las pacientes fueron transferidas con un blastocito euploide biopsiado único, y su endometrio fue preparado con terapia de reemplazo hormonal (HRT). El grosor endometrial en el día de transferencia del blastocito y la administración de progesterona fueron medidos por ecografía transvaginal, y la diferencia entre ellos y la proporción de cambio fueron calculadas. índices de embarazo clínico y nacidos vivos. Imágenes de ecografía endometrial de 508 ciclos de transferencia de blastocito euploide usando HRT fueron evaluados por ecografía transvaginal. En general, los resultados de embarazo fueron comparables entre los diferentes grupos de cambio de grosor endometrial. Los resultados de la regresión múltiple logística demostraron que los índices de embarazo clínico y nacidos vivos no aumentaron significativamente con el aumento de la proporción de cambio del grosor endometrial (por 10%) en el modelo ajustado completo como una variable continua. En el modelo ajustado como una variable categórica, no hubo diferencias estadísticas en los resultados de embarazo entre los grupos de cambio de grosor endometrial. El análisis de interacción demostró que luego de ajustar por variables de confusión, no hubo interacción estadísticamente significativa entre la proporción de cambio de grosor endometrial y los resultados de embarazo entre todos los subgrupos. En los ciclos de transferencias de blastocitos euploides preparando el endometrio con HRT, la proporción de cambio del grosor endometrial luego de la administración de progesterona no fue relacionado con los resultados de embarazo.</description><subject>Adult</subject><subject>Cohort Studies</subject><subject>Cryopreservation - trends</subject><subject>Embryo Transfer - trends</subject><subject>Endometrial thickness change ratio</subject><subject>Endometrium - diagnostic imaging</subject><subject>Endometrium - drug effects</subject><subject>euploid blastocyst transfer</subject><subject>Female</subject><subject>hormone replacement therapy</subject><subject>Humans</subject><subject>Organ Size - drug effects</subject><subject>Pregnancy</subject><subject>Pregnancy Outcome - epidemiology</subject><subject>pregnancy outcomes</subject><subject>Progesterone - administration &amp; dosage</subject><subject>Retrospective Studies</subject><subject>transvaginal ultrasound</subject><issn>0015-0282</issn><issn>1556-5653</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUcuOFCEUJUbjtKO_YFi6qRKqCop2p5PxkUziRteEx2WathpaoMa0P-Uveic96tINcJPzuIdDCOWs54zL1_s-QGmpNjz7gQ28Z6pnTD0iGy6E7IQU42OyYYyLjg1quCDPat0zxiSfh6fkYpzEqCbJN-TXdfL5AK1Es9C2i-5bglqp25l0C5WagBb0WDIO-MoJqPGHmGJtxbSYE_WZptwQGMA1VABEw20yyZ1oXptD8UpzoKHkn5C6tjM_wFNYj0uOntrF1JbdqSK1mFQx1htqaMGFcj2iYrwD6vIul0ZrW_3pOXkSzFLhxcN9Sb6-v_5y9bG7-fzh09Xbm86N89Q6a0cnZgEBjJu3VrmJDcCUmBTb8sCklyLIoNRkvOVitN7OW-OlDRJGqawYL8mrsy5m_75ieH2I1cGymAR5rXoQ8zSPis1bhKoz1OHOtUDQxxIPppw0Z_q-Lr3X_-rS93VppjTWhdSXDy6rPYD_S_zTDwLenQGAWe8iFF1dhOTAx4K_o32O_3f5DTPesxg</recordid><startdate>202112</startdate><enddate>202112</enddate><creator>Jin, Ziqi</creator><creator>Shi, Hao</creator><creator>Lu, Manman</creator><creator>Bu, Zhiqin</creator><creator>Huo, Mingzhu</creator><creator>Zhang, Yile</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202112</creationdate><title>Endometrial thickness changes after progesterone administration do not affect the pregnancy outcomes of frozen-thawed euploid blastocyst transfer: a retrospective cohort study</title><author>Jin, Ziqi ; 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Observational cohort study. Single reproductive medical center. All patients were transferred with a single biopsied euploid blastocyst, and their endometrium was prepared with hormone replacement therapy (HRT). The endometrial thickness on the day of blastocyst transfer and progesterone administration was measured by transvaginal ultrasound, and the difference between them and the change ratio were calculated. Clinical pregnancy rates and live birth rates. Endometrial ultrasound images of 508 euploid blastocyst transfer cycles using HRT were evaluated by transvaginal ultrasound. Overall, pregnancy outcomes were comparable in different groups of endometrial thickness changes. The results of multiple logistic regression showed that the clinical pregnancy rate and live birth rate did not significantly increase with the increase in endometrial thickness change ratios (per 10%) in the fully adjusted model as a continuous variable. In the adjustment model as a categorical variable, there was no statistical difference in pregnancy outcomes among the groups with changes in endometrial thickness. Interaction analysis showed that after adjusting for confounders, there was no statistically significant interaction between the endometrial thickness change ratio and pregnancy outcomes in all subgroups. In the euploid blastocyst transfer cycle of preparing the endometrium with HRT, the endometrial thickness change ratio after progesterone administration was not related to pregnancy outcomes. Cambios en el grosor endometrial luego de la administración de progesterona no afecta los resultados de embarazo de la transferencia congelado-descongelado del blastocito euploide: un estudio de cohorte retrospectivo. Evaluar si el cambio en el grosor endometrial entre el día de administración de progesterona y el día de transferencia está relacionado con los resultados de embarazo de los ciclos de transferencia congelado-descongelado de blastocitos euploides únicos. estudio cohorte observacional. centro de medicina reproductiva único. Todas las pacientes fueron transferidas con un blastocito euploide biopsiado único, y su endometrio fue preparado con terapia de reemplazo hormonal (HRT). El grosor endometrial en el día de transferencia del blastocito y la administración de progesterona fueron medidos por ecografía transvaginal, y la diferencia entre ellos y la proporción de cambio fueron calculadas. índices de embarazo clínico y nacidos vivos. Imágenes de ecografía endometrial de 508 ciclos de transferencia de blastocito euploide usando HRT fueron evaluados por ecografía transvaginal. En general, los resultados de embarazo fueron comparables entre los diferentes grupos de cambio de grosor endometrial. Los resultados de la regresión múltiple logística demostraron que los índices de embarazo clínico y nacidos vivos no aumentaron significativamente con el aumento de la proporción de cambio del grosor endometrial (por 10%) en el modelo ajustado completo como una variable continua. En el modelo ajustado como una variable categórica, no hubo diferencias estadísticas en los resultados de embarazo entre los grupos de cambio de grosor endometrial. El análisis de interacción demostró que luego de ajustar por variables de confusión, no hubo interacción estadísticamente significativa entre la proporción de cambio de grosor endometrial y los resultados de embarazo entre todos los subgrupos. En los ciclos de transferencias de blastocitos euploides preparando el endometrio con HRT, la proporción de cambio del grosor endometrial luego de la administración de progesterona no fue relacionado con los resultados de embarazo.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>34538461</pmid><doi>10.1016/j.fertnstert.2021.08.008</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record>
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subjects Adult
Cohort Studies
Cryopreservation - trends
Embryo Transfer - trends
Endometrial thickness change ratio
Endometrium - diagnostic imaging
Endometrium - drug effects
euploid blastocyst transfer
Female
hormone replacement therapy
Humans
Organ Size - drug effects
Pregnancy
Pregnancy Outcome - epidemiology
pregnancy outcomes
Progesterone - administration & dosage
Retrospective Studies
transvaginal ultrasound
title Endometrial thickness changes after progesterone administration do not affect the pregnancy outcomes of frozen-thawed euploid blastocyst transfer: a retrospective cohort study
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