Endometrial thickness changes after progesterone administration do not affect the pregnancy outcomes of frozen-thawed euploid blastocyst transfer: a retrospective cohort study

To evaluate whether the change in endometrial thickness from progesterone administration day to transfer day is related to pregnancy outcomes in single frozen-thawed euploid blastocyst transfer cycles. Observational cohort study. Single reproductive medical center. All patients were transferred with a single biopsied euploid blastocyst, and their endometrium was prepared with hormone replacement therapy (HRT). The endometrial thickness on the day of blastocyst transfer and progesterone administration was measured by transvaginal ultrasound, and the difference between them and the change ratio were calculated. Clinical pregnancy rates and live birth rates. Endometrial ultrasound images of 508 euploid blastocyst transfer cycles using HRT were evaluated by transvaginal ultrasound. Overall, pregnancy outcomes were comparable in different groups of endometrial thickness changes. The results of multiple logistic regression showed that the clinical pregnancy rate and live birth rate did not significantly increase with the increase in endometrial thickness change ratios (per 10%) in the fully adjusted model as a continuous variable. In the adjustment model as a categorical variable, there was no statistical difference in pregnancy outcomes among the groups with changes in endometrial thickness. Interaction analysis showed that after adjusting for confounders, there was no statistically significant interaction between the endometrial thickness change ratio and pregnancy outcomes in all subgroups. In the euploid blastocyst transfer cycle of preparing the endometrium with HRT, the endometrial thickness change ratio after progesterone administration was not related to pregnancy outcomes. Cambios en el grosor endometrial luego de la administración de progesterona no afecta los resultados de embarazo de la transferencia congelado-descongelado del blastocito euploide: un estudio de cohorte retrospectivo. Evaluar si el cambio en el grosor endometrial entre el día de administración de progesterona y el día de transferencia está relacionado con los resultados de embarazo de los ciclos de transferencia congelado-descongelado de blastocitos euploides únicos. estudio cohorte observacional. centro de medicina reproductiva único. Todas las pacientes fueron transferidas con un blastocito euploide biopsiado único, y su endometrio fue preparado con terapia de reemplazo hormonal (HRT). El grosor endometrial en el día de transferencia del blastocito y la administración de progesteron