Safety and Immunogenicity of an Anti–Zika Virus DNA Vaccine
There are no known specific therapies or vaccines to treat or prevent Zika virus infection. In this report, encouraging data are presented from a phase 1 study of a DNA vaccine against ZIKV infection.
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| Veröffentlicht in: | The New England journal of medicine 2021-09, Vol.385 (12), p.e35 |
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| container_issue | 12 |
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| container_title | The New England journal of medicine |
| container_volume | 385 |
| creator | Tebas, Pablo Roberts, Christine C Muthumani, Kar Reuschel, Emma L Kudchodkar, Sagar B Zaidi, Faraz I White, Scott Khan, Amir S Racine, Trina Choi, Hyeree Boyer, Jean Park, Young K Trottier, Sylvie Remigio, Celine Krieger, Diane Spruill, Susan E Bagarazzi, Mark Kobinger, Gary P Weiner, David B Maslow, Joel N |
| description | There are no known specific therapies or vaccines to treat or prevent Zika virus infection. In this report, encouraging data are presented from a phase 1 study of a DNA vaccine against ZIKV infection. |
| doi_str_mv | 10.1056/NEJMoa1708120 |
| format | Article |
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In this report, encouraging data are presented from a phase 1 study of a DNA vaccine against ZIKV infection.</description><identifier>ISSN: 0028-4793</identifier><identifier>ISSN: 1533-4406</identifier><identifier>EISSN: 1533-4406</identifier><identifier>DOI: 10.1056/NEJMoa1708120</identifier><identifier>PMID: 34525286</identifier><language>eng</language><publisher>United States: Massachusetts Medical Society</publisher><subject>Adult ; Adverse events ; Animals ; Antibodies ; Antibodies, Neutralizing - blood ; Antibodies, Viral - blood ; Clinical trials ; Confidence intervals ; Congenital defects ; Dengue fever ; Deoxyribonucleic acid ; DNA ; DNA vaccines ; DNA viruses ; Electroporation ; Enzyme-linked immunosorbent assay ; Enzymes ; FDA approval ; Female ; Global Health ; Guillain-Barre syndrome ; Humans ; Immune response ; Immunization ; Immunogenicity ; Immunogenicity, Vaccine ; Infections ; Infectious Disease ; Injection ; Injections, Intradermal - adverse effects ; Laboratories ; Lethal dose ; Life sciences ; Male ; Mice ; Mice, Knockout ; Middle Aged ; Nucleotide sequence ; Peptides ; Safety ; T-Lymphocytes - physiology ; Vaccines ; Vaccines, DNA - administration & dosage ; Vaccines, DNA - adverse effects ; Vaccines, DNA - immunology ; Viral Infections ; Viral Vaccines - immunology ; Zika virus ; Zika Virus - immunology ; Zika Virus Infection - immunology ; Zika Virus Infection - prevention & control ; α-Interferon ; β-Interferon</subject><ispartof>The New England journal of medicine, 2021-09, Vol.385 (12), p.e35</ispartof><rights>Copyright © 2017 Massachusetts Medical Society. All rights reserved.</rights><rights>Copyright © 2017 Massachusetts Medical Society.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c434t-f4799eb468ccc4c52f38f56c131d6b312baab098f821cc929851467a000c6283</citedby><cites>FETCH-LOGICAL-c434t-f4799eb468ccc4c52f38f56c131d6b312baab098f821cc929851467a000c6283</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.nejm.org/doi/pdf/10.1056/NEJMoa1708120$$EPDF$$P50$$Gmms$$H</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2572972563?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,2759,2760,26103,27924,27925,52382,54064,64385,64387,64389,72469</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34525286$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tebas, Pablo</creatorcontrib><creatorcontrib>Roberts, Christine C</creatorcontrib><creatorcontrib>Muthumani, Kar</creatorcontrib><creatorcontrib>Reuschel, Emma L</creatorcontrib><creatorcontrib>Kudchodkar, Sagar B</creatorcontrib><creatorcontrib>Zaidi, Faraz I</creatorcontrib><creatorcontrib>White, Scott</creatorcontrib><creatorcontrib>Khan, Amir S</creatorcontrib><creatorcontrib>Racine, Trina</creatorcontrib><creatorcontrib>Choi, Hyeree</creatorcontrib><creatorcontrib>Boyer, Jean</creatorcontrib><creatorcontrib>Park, Young K</creatorcontrib><creatorcontrib>Trottier, Sylvie</creatorcontrib><creatorcontrib>Remigio, Celine</creatorcontrib><creatorcontrib>Krieger, Diane</creatorcontrib><creatorcontrib>Spruill, Susan E</creatorcontrib><creatorcontrib>Bagarazzi, Mark</creatorcontrib><creatorcontrib>Kobinger, Gary P</creatorcontrib><creatorcontrib>Weiner, David B</creatorcontrib><creatorcontrib>Maslow, Joel N</creatorcontrib><title>Safety and Immunogenicity of an Anti–Zika Virus DNA Vaccine</title><title>The New England journal of medicine</title><addtitle>N Engl J Med</addtitle><description>There are no known specific therapies or vaccines to treat or prevent Zika virus infection. In this report, encouraging data are presented from a phase 1 study of a DNA vaccine against ZIKV infection.</description><subject>Adult</subject><subject>Adverse events</subject><subject>Animals</subject><subject>Antibodies</subject><subject>Antibodies, Neutralizing - blood</subject><subject>Antibodies, Viral - blood</subject><subject>Clinical trials</subject><subject>Confidence intervals</subject><subject>Congenital defects</subject><subject>Dengue fever</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>DNA vaccines</subject><subject>DNA viruses</subject><subject>Electroporation</subject><subject>Enzyme-linked immunosorbent assay</subject><subject>Enzymes</subject><subject>FDA approval</subject><subject>Female</subject><subject>Global Health</subject><subject>Guillain-Barre syndrome</subject><subject>Humans</subject><subject>Immune response</subject><subject>Immunization</subject><subject>Immunogenicity</subject><subject>Immunogenicity, Vaccine</subject><subject>Infections</subject><subject>Infectious Disease</subject><subject>Injection</subject><subject>Injections, Intradermal - adverse effects</subject><subject>Laboratories</subject><subject>Lethal dose</subject><subject>Life sciences</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Knockout</subject><subject>Middle Aged</subject><subject>Nucleotide sequence</subject><subject>Peptides</subject><subject>Safety</subject><subject>T-Lymphocytes - physiology</subject><subject>Vaccines</subject><subject>Vaccines, DNA - administration & dosage</subject><subject>Vaccines, DNA - adverse effects</subject><subject>Vaccines, DNA - immunology</subject><subject>Viral Infections</subject><subject>Viral Vaccines - immunology</subject><subject>Zika virus</subject><subject>Zika Virus - immunology</subject><subject>Zika Virus Infection - immunology</subject><subject>Zika Virus Infection - prevention & control</subject><subject>α-Interferon</subject><subject>β-Interferon</subject><issn>0028-4793</issn><issn>1533-4406</issn><issn>1533-4406</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp10D1LAzEcBvAgiq3V0VUORHA5zfslg0OpVSu1DpYOLkcuTeRqk6uX3tDN7-A39JOY0ioomCXw58fDwwPAMYIXCDJ-OerfP1QKZVAgDHdAGzFCUkoh3wVtCLFIaSZJCxyEMIPxISr3QYtQhhkWvA2unpQ1y1Wi_DQZONf46sX4UpfxVNl4Tbp-WX6-fzyXryqZlHUTkutRN5korUtvDsGeVfNgjrZ_B4xv-uPeXTp8vB30usNUU0KXqY0dpCkoF1prqhm2RFjGNSJoyguCcKFUAaWwAiOtJZaCIcozFftqjgXpgPNN7KKu3hoTlrkrgzbzufKmakKOWUYoEULySE__0FnV1D6WWyssM8w4iSrdKF1XIdTG5ou6dKpe5Qjm61nzX7NGf7JNbQpnpj_6e8cIzjbAuZB7M3P_BH0BpaB71w</recordid><startdate>20210916</startdate><enddate>20210916</enddate><creator>Tebas, Pablo</creator><creator>Roberts, Christine C</creator><creator>Muthumani, Kar</creator><creator>Reuschel, Emma L</creator><creator>Kudchodkar, Sagar B</creator><creator>Zaidi, Faraz I</creator><creator>White, Scott</creator><creator>Khan, Amir S</creator><creator>Racine, Trina</creator><creator>Choi, Hyeree</creator><creator>Boyer, Jean</creator><creator>Park, Young K</creator><creator>Trottier, Sylvie</creator><creator>Remigio, Celine</creator><creator>Krieger, Diane</creator><creator>Spruill, Susan E</creator><creator>Bagarazzi, Mark</creator><creator>Kobinger, Gary P</creator><creator>Weiner, David B</creator><creator>Maslow, Joel N</creator><general>Massachusetts Medical Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0TZ</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K0Y</scope><scope>LK8</scope><scope>M0R</scope><scope>M0T</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20210916</creationdate><title>Safety and Immunogenicity of an Anti–Zika Virus DNA Vaccine</title><author>Tebas, Pablo ; Roberts, Christine C ; Muthumani, Kar ; Reuschel, Emma L ; Kudchodkar, Sagar B ; Zaidi, Faraz I ; White, Scott ; Khan, Amir S ; Racine, Trina ; Choi, Hyeree ; Boyer, Jean ; Park, Young K ; Trottier, Sylvie ; Remigio, Celine ; Krieger, Diane ; Spruill, Susan E ; Bagarazzi, Mark ; Kobinger, Gary P ; Weiner, David B ; Maslow, Joel N</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c434t-f4799eb468ccc4c52f38f56c131d6b312baab098f821cc929851467a000c6283</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adult</topic><topic>Adverse events</topic><topic>Animals</topic><topic>Antibodies</topic><topic>Antibodies, Neutralizing - 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In this report, encouraging data are presented from a phase 1 study of a DNA vaccine against ZIKV infection.</abstract><cop>United States</cop><pub>Massachusetts Medical Society</pub><pmid>34525286</pmid><doi>10.1056/NEJMoa1708120</doi><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0028-4793 |
| ispartof | The New England journal of medicine, 2021-09, Vol.385 (12), p.e35 |
| issn | 0028-4793 1533-4406 1533-4406 |
| language | eng |
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| source | MEDLINE; New England Journal of Medicine Current; EZB-FREE-00999 freely available EZB journals; ProQuest Central UK/Ireland |
| subjects | Adult Adverse events Animals Antibodies Antibodies, Neutralizing - blood Antibodies, Viral - blood Clinical trials Confidence intervals Congenital defects Dengue fever Deoxyribonucleic acid DNA DNA vaccines DNA viruses Electroporation Enzyme-linked immunosorbent assay Enzymes FDA approval Female Global Health Guillain-Barre syndrome Humans Immune response Immunization Immunogenicity Immunogenicity, Vaccine Infections Infectious Disease Injection Injections, Intradermal - adverse effects Laboratories Lethal dose Life sciences Male Mice Mice, Knockout Middle Aged Nucleotide sequence Peptides Safety T-Lymphocytes - physiology Vaccines Vaccines, DNA - administration & dosage Vaccines, DNA - adverse effects Vaccines, DNA - immunology Viral Infections Viral Vaccines - immunology Zika virus Zika Virus - immunology Zika Virus Infection - immunology Zika Virus Infection - prevention & control α-Interferon β-Interferon |
| title | Safety and Immunogenicity of an Anti–Zika Virus DNA Vaccine |
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