Safety and Immunogenicity of an Anti–Zika Virus DNA Vaccine

There are no known specific therapies or vaccines to treat or prevent Zika virus infection. In this report, encouraging data are presented from a phase 1 study of a DNA vaccine against ZIKV infection.

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Bibliographische Detailangaben
Veröffentlicht in:	The New England journal of medicine 2021-09, Vol.385 (12), p.e35
Hauptverfasser:	Tebas, Pablo, Roberts, Christine C, Muthumani, Kar, Reuschel, Emma L, Kudchodkar, Sagar B, Zaidi, Faraz I, White, Scott, Khan, Amir S, Racine, Trina, Choi, Hyeree, Boyer, Jean, Park, Young K, Trottier, Sylvie, Remigio, Celine, Krieger, Diane, Spruill, Susan E, Bagarazzi, Mark, Kobinger, Gary P, Weiner, David B, Maslow, Joel N
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Adverse events Animals Antibodies Antibodies, Neutralizing - blood Antibodies, Viral - blood Clinical trials Confidence intervals Congenital defects Dengue fever Deoxyribonucleic acid DNA DNA vaccines DNA viruses Electroporation Enzyme-linked immunosorbent assay Enzymes FDA approval Female Global Health Guillain-Barre syndrome Humans Immune response Immunization Immunogenicity Immunogenicity, Vaccine Infections Infectious Disease Injection Injections, Intradermal - adverse effects Laboratories Lethal dose Life sciences Male Mice Mice, Knockout Middle Aged Nucleotide sequence Peptides Safety T-Lymphocytes - physiology Vaccines Vaccines, DNA - administration & dosage Vaccines, DNA - adverse effects Vaccines, DNA - immunology Viral Infections Viral Vaccines - immunology Zika virus Zika Virus - immunology Zika Virus Infection - immunology Zika Virus Infection - prevention & control α-Interferon β-Interferon
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Beschreibung
Zusammenfassung:	There are no known specific therapies or vaccines to treat or prevent Zika virus infection. In this report, encouraging data are presented from a phase 1 study of a DNA vaccine against ZIKV infection.
ISSN:	0028-4793 1533-4406 1533-4406
DOI:	10.1056/NEJMoa1708120