Survival outcomes associated with completion of adjuvant oxaliplatin‐based chemotherapy for stage III colon cancer: A national population‐based study
The impact of cycle completion rates of oxaliplatin‐based adjuvant chemotherapy for stage III colon cancer in real‐world practice is unknown. We assessed its impact, and that of treatment modification, on 3‐year cancer‐specific mortality. Four thousand one hundred and forty‐seven patients with patho...
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| description | The impact of cycle completion rates of oxaliplatin‐based adjuvant chemotherapy for stage III colon cancer in real‐world practice is unknown. We assessed its impact, and that of treatment modification, on 3‐year cancer‐specific mortality. Four thousand one hundred and forty‐seven patients with pathological stage III colon cancer undergoing major resection from 2014 to 2017 in the English National Health Service were included. Chemotherapy data came from linked national administrative datasets. Competing risk regression analysis for 3‐year cancer‐specific mortality was performed according to completion of |
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What's new?
Adjuvant chemotherapy following curative surgical resection is an established treatment for stage III colon cancer. However, many patients do not complete the planned duration of chemotherapy. This is the largest cohort study in real‐world practice to evaluate cancer‐specific survival according to the cycle completion rate of oxaliplatin‐based adjuvant chemotherapy in stage III colon cancer patients, and the first to assess the impact of treatment modification strategies. The results show that patients who do not complete their planned cycles have significantly poorer outcomes. In the absence of demonstrated negative impacts, clinicians could use treatment modifications to facilitate completion of adjuvant chemotherapy.]]></description><identifier>ISSN: 0020-7136</identifier><identifier>EISSN: 1097-0215</identifier><identifier>DOI: 10.1002/ijc.33806</identifier><identifier>PMID: 34520572</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley & Sons, Inc</publisher><subject>adjuvant chemotherapy ; Aged ; Aged, 80 and over ; Antineoplastic Combined Chemotherapy Protocols - therapeutic use ; Cancer ; Capecitabine - administration & dosage ; Chemotherapy ; Chemotherapy, Adjuvant - mortality ; Colon cancer ; Colonic Neoplasms - drug therapy ; Colonic Neoplasms - mortality ; Colonic Neoplasms - pathology ; Colorectal cancer ; completion of treatment ; epidemiology ; Female ; Fluorouracil - administration & dosage ; Follow-Up Studies ; Humans ; Leucovorin - administration & dosage ; Male ; Medical prognosis ; Medical research ; Middle Aged ; Mortality ; Neoplasm Staging ; Oxaliplatin ; Oxaliplatin - administration & dosage ; Patients ; Population studies ; Population-based studies ; Prospective Studies ; stage III ; Survival ; Survival Rate ; Tumors</subject><ispartof>International journal of cancer, 2022-01, Vol.150 (2), p.335-346</ispartof><rights>2021 The Authors. published by John Wiley & Sons Ltd on behalf of UICC.</rights><rights>2021 The Authors. International Journal of Cancer published by John Wiley & Sons Ltd on behalf of UICC.</rights><rights>2021. This article is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3886-c2ec4e7b83876e7a72b402a4bd40b28fb12167df486c3a33c66b4702e11acf323</citedby><cites>FETCH-LOGICAL-c3886-c2ec4e7b83876e7a72b402a4bd40b28fb12167df486c3a33c66b4702e11acf323</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fijc.33806$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fijc.33806$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34520572$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Boyle, Jemma M.</creatorcontrib><creatorcontrib>Kuryba, Angela</creatorcontrib><creatorcontrib>Cowling, Thomas E.</creatorcontrib><creatorcontrib>Meulen, Jan</creatorcontrib><creatorcontrib>Fearnhead, Nicola S.</creatorcontrib><creatorcontrib>Walker, Kate</creatorcontrib><creatorcontrib>Braun, Michael S.</creatorcontrib><creatorcontrib>Aggarwal, Ajay</creatorcontrib><title>Survival outcomes associated with completion of adjuvant oxaliplatin‐based chemotherapy for stage III colon cancer: A national population‐based study</title><title>International journal of cancer</title><addtitle>Int J Cancer</addtitle><description><![CDATA[The impact of cycle completion rates of oxaliplatin‐based adjuvant chemotherapy for stage III colon cancer in real‐world practice is unknown. We assessed its impact, and that of treatment modification, on 3‐year cancer‐specific mortality. Four thousand one hundred and forty‐seven patients with pathological stage III colon cancer undergoing major resection from 2014 to 2017 in the English National Health Service were included. Chemotherapy data came from linked national administrative datasets. Competing risk regression analysis for 3‐year cancer‐specific mortality was performed according to completion of <6, 6‐11, or 12 5‐fluoropyrimidine and oxaliplatin (FOLFOX) cycles, or <4, 4‐7, or 8 capecitabine and oxaliplatin (CAPOX) cycles, adjusted for patient, tumour and hospital‐level characteristics. Median age was 64 years. Thirty‐two per cent of patients had at least one comorbidity. Forty‐two per cent of patients had T4 disease, and 40% had N2 disease. Compared to completion of 12 FOLFOX cycles, cancer‐specific mortality was higher in patients completing <6 cycles [subdistribution hazard ratios (sHR) 2.17; 95% CI 1.56‐3.03] or 6‐11 cycles (sHR 1.40; 95% CI 1.09‐1.78) (P < .001). Compared to completion of 8 CAPOX cycles, cancer‐specific mortality was higher in patients completing <4 cycles (sHR 2.02; 95% CI 1.53‐2.67) or 4‐7 cycles (sHR 1.63; 95% CI 1.27‐2.10) (P < .001). Dose reduction and early oxaliplatin discontinuation did not impact mortality in patients completing all cycles. Completion of all cycles of chemotherapy was associated with improved cancer‐specific survival in real‐world practice. Poor prognostic factors may have affected findings, however, patients completing <50% of cycles had poor outcomes. Clinicians may wish to facilitate completion with treatment modification in those able to tolerate it.
What's new?
Adjuvant chemotherapy following curative surgical resection is an established treatment for stage III colon cancer. However, many patients do not complete the planned duration of chemotherapy. This is the largest cohort study in real‐world practice to evaluate cancer‐specific survival according to the cycle completion rate of oxaliplatin‐based adjuvant chemotherapy in stage III colon cancer patients, and the first to assess the impact of treatment modification strategies. The results show that patients who do not complete their planned cycles have significantly poorer outcomes. In the absence of demonstrated negative impacts, clinicians could use treatment modifications to facilitate completion of adjuvant chemotherapy.]]></description><subject>adjuvant chemotherapy</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</subject><subject>Cancer</subject><subject>Capecitabine - administration & dosage</subject><subject>Chemotherapy</subject><subject>Chemotherapy, Adjuvant - mortality</subject><subject>Colon cancer</subject><subject>Colonic Neoplasms - drug therapy</subject><subject>Colonic Neoplasms - mortality</subject><subject>Colonic Neoplasms - pathology</subject><subject>Colorectal cancer</subject><subject>completion of treatment</subject><subject>epidemiology</subject><subject>Female</subject><subject>Fluorouracil - administration & dosage</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Leucovorin - administration & dosage</subject><subject>Male</subject><subject>Medical prognosis</subject><subject>Medical research</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Neoplasm Staging</subject><subject>Oxaliplatin</subject><subject>Oxaliplatin - administration & dosage</subject><subject>Patients</subject><subject>Population studies</subject><subject>Population-based studies</subject><subject>Prospective Studies</subject><subject>stage III</subject><subject>Survival</subject><subject>Survival Rate</subject><subject>Tumors</subject><issn>0020-7136</issn><issn>1097-0215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>EIF</sourceid><recordid>eNp1kctu1DAUhi0EokNhwQsgS2zKIq1vsTPsqhGXoEosgHV04jiMR04cfJkyOx6BLa_Hk-B2ShdIrKzj8-k7OudH6Dkl55QQdmF3-pzzhsgHaEXJWlWE0fohWpUeqRTl8gQ9iXFHCKU1EY_RCRc1I7ViK_TrUw57uweHfU7aTyZiiNFrC8kM-NqmLS6_izPJ-hn7EcOwy3uYE_bfwdnFQbLz7x8_e4iF11sz-bQ1AZYDHn3AMcFXg9u2LRZXBBpmbcJrfIlnuDGWuYtfsrst7jUx5eHwFD0awUXz7O49RV_evvm8eV9dfXzXbi6vKs2bRlaaGS2M6hveKGkUKNYLwkD0gyA9a8aeMirVMIpGag6cayl7oQgzlIIeOeOn6OzoXYL_lk1M3WSjNs7BbHyOHSt3WnNJqCjoy3_Qnc-hLFEoSRgXqhbrQr06Ujr4GIMZuyXYCcKho6S7yasreXW3eRX2xZ0x95MZ7sm_ARXg4ghcW2cO_zd17YfNUfkH1vqjWA</recordid><startdate>20220115</startdate><enddate>20220115</enddate><creator>Boyle, Jemma M.</creator><creator>Kuryba, Angela</creator><creator>Cowling, Thomas E.</creator><creator>Meulen, Jan</creator><creator>Fearnhead, Nicola S.</creator><creator>Walker, Kate</creator><creator>Braun, Michael S.</creator><creator>Aggarwal, Ajay</creator><general>John Wiley & Sons, Inc</general><general>Wiley Subscription Services, Inc</general><scope>24P</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TO</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>20220115</creationdate><title>Survival outcomes associated with completion of adjuvant oxaliplatin‐based chemotherapy for stage III colon cancer: A national population‐based study</title><author>Boyle, Jemma M. ; Kuryba, Angela ; Cowling, Thomas E. ; Meulen, Jan ; Fearnhead, Nicola S. ; Walker, Kate ; Braun, Michael S. ; Aggarwal, Ajay</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3886-c2ec4e7b83876e7a72b402a4bd40b28fb12167df486c3a33c66b4702e11acf323</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>adjuvant chemotherapy</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</topic><topic>Cancer</topic><topic>Capecitabine - administration & dosage</topic><topic>Chemotherapy</topic><topic>Chemotherapy, Adjuvant - mortality</topic><topic>Colon cancer</topic><topic>Colonic Neoplasms - drug therapy</topic><topic>Colonic Neoplasms - mortality</topic><topic>Colonic Neoplasms - pathology</topic><topic>Colorectal cancer</topic><topic>completion of treatment</topic><topic>epidemiology</topic><topic>Female</topic><topic>Fluorouracil - administration & dosage</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Leucovorin - administration & dosage</topic><topic>Male</topic><topic>Medical prognosis</topic><topic>Medical research</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Neoplasm Staging</topic><topic>Oxaliplatin</topic><topic>Oxaliplatin - administration & dosage</topic><topic>Patients</topic><topic>Population studies</topic><topic>Population-based studies</topic><topic>Prospective Studies</topic><topic>stage III</topic><topic>Survival</topic><topic>Survival Rate</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Boyle, Jemma M.</creatorcontrib><creatorcontrib>Kuryba, Angela</creatorcontrib><creatorcontrib>Cowling, Thomas E.</creatorcontrib><creatorcontrib>Meulen, Jan</creatorcontrib><creatorcontrib>Fearnhead, Nicola S.</creatorcontrib><creatorcontrib>Walker, Kate</creatorcontrib><creatorcontrib>Braun, Michael S.</creatorcontrib><creatorcontrib>Aggarwal, Ajay</creatorcontrib><collection>Wiley Online Library Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Boyle, Jemma M.</au><au>Kuryba, Angela</au><au>Cowling, Thomas E.</au><au>Meulen, Jan</au><au>Fearnhead, Nicola S.</au><au>Walker, Kate</au><au>Braun, Michael S.</au><au>Aggarwal, Ajay</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Survival outcomes associated with completion of adjuvant oxaliplatin‐based chemotherapy for stage III colon cancer: A national population‐based study</atitle><jtitle>International journal of cancer</jtitle><addtitle>Int J Cancer</addtitle><date>2022-01-15</date><risdate>2022</risdate><volume>150</volume><issue>2</issue><spage>335</spage><epage>346</epage><pages>335-346</pages><issn>0020-7136</issn><eissn>1097-0215</eissn><abstract><![CDATA[The impact of cycle completion rates of oxaliplatin‐based adjuvant chemotherapy for stage III colon cancer in real‐world practice is unknown. We assessed its impact, and that of treatment modification, on 3‐year cancer‐specific mortality. Four thousand one hundred and forty‐seven patients with pathological stage III colon cancer undergoing major resection from 2014 to 2017 in the English National Health Service were included. Chemotherapy data came from linked national administrative datasets. Competing risk regression analysis for 3‐year cancer‐specific mortality was performed according to completion of <6, 6‐11, or 12 5‐fluoropyrimidine and oxaliplatin (FOLFOX) cycles, or <4, 4‐7, or 8 capecitabine and oxaliplatin (CAPOX) cycles, adjusted for patient, tumour and hospital‐level characteristics. Median age was 64 years. Thirty‐two per cent of patients had at least one comorbidity. Forty‐two per cent of patients had T4 disease, and 40% had N2 disease. Compared to completion of 12 FOLFOX cycles, cancer‐specific mortality was higher in patients completing <6 cycles [subdistribution hazard ratios (sHR) 2.17; 95% CI 1.56‐3.03] or 6‐11 cycles (sHR 1.40; 95% CI 1.09‐1.78) (P < .001). Compared to completion of 8 CAPOX cycles, cancer‐specific mortality was higher in patients completing <4 cycles (sHR 2.02; 95% CI 1.53‐2.67) or 4‐7 cycles (sHR 1.63; 95% CI 1.27‐2.10) (P < .001). Dose reduction and early oxaliplatin discontinuation did not impact mortality in patients completing all cycles. Completion of all cycles of chemotherapy was associated with improved cancer‐specific survival in real‐world practice. Poor prognostic factors may have affected findings, however, patients completing <50% of cycles had poor outcomes. Clinicians may wish to facilitate completion with treatment modification in those able to tolerate it.
What's new?
Adjuvant chemotherapy following curative surgical resection is an established treatment for stage III colon cancer. However, many patients do not complete the planned duration of chemotherapy. This is the largest cohort study in real‐world practice to evaluate cancer‐specific survival according to the cycle completion rate of oxaliplatin‐based adjuvant chemotherapy in stage III colon cancer patients, and the first to assess the impact of treatment modification strategies. The results show that patients who do not complete their planned cycles have significantly poorer outcomes. In the absence of demonstrated negative impacts, clinicians could use treatment modifications to facilitate completion of adjuvant chemotherapy.]]></abstract><cop>Hoboken, USA</cop><pub>John Wiley & Sons, Inc</pub><pmid>34520572</pmid><doi>10.1002/ijc.33806</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | adjuvant chemotherapy Aged Aged, 80 and over Antineoplastic Combined Chemotherapy Protocols - therapeutic use Cancer Capecitabine - administration & dosage Chemotherapy Chemotherapy, Adjuvant - mortality Colon cancer Colonic Neoplasms - drug therapy Colonic Neoplasms - mortality Colonic Neoplasms - pathology Colorectal cancer completion of treatment epidemiology Female Fluorouracil - administration & dosage Follow-Up Studies Humans Leucovorin - administration & dosage Male Medical prognosis Medical research Middle Aged Mortality Neoplasm Staging Oxaliplatin Oxaliplatin - administration & dosage Patients Population studies Population-based studies Prospective Studies stage III Survival Survival Rate Tumors |
| title | Survival outcomes associated with completion of adjuvant oxaliplatin‐based chemotherapy for stage III colon cancer: A national population‐based study |
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