Survival outcomes associated with completion of adjuvant oxaliplatin‐based chemotherapy for stage III colon cancer: A national population‐based study

The impact of cycle completion rates of oxaliplatin‐based adjuvant chemotherapy for stage III colon cancer in real‐world practice is unknown. We assessed its impact, and that of treatment modification, on 3‐year cancer‐specific mortality. Four thousand one hundred and forty‐seven patients with patho...

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Veröffentlicht in:International journal of cancer 2022-01, Vol.150 (2), p.335-346
Hauptverfasser: Boyle, Jemma M., Kuryba, Angela, Cowling, Thomas E., Meulen, Jan, Fearnhead, Nicola S., Walker, Kate, Braun, Michael S., Aggarwal, Ajay
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Sprache:eng
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Zusammenfassung:The impact of cycle completion rates of oxaliplatin‐based adjuvant chemotherapy for stage III colon cancer in real‐world practice is unknown. We assessed its impact, and that of treatment modification, on 3‐year cancer‐specific mortality. Four thousand one hundred and forty‐seven patients with pathological stage III colon cancer undergoing major resection from 2014 to 2017 in the English National Health Service were included. Chemotherapy data came from linked national administrative datasets. Competing risk regression analysis for 3‐year cancer‐specific mortality was performed according to completion of
ISSN:0020-7136
1097-0215
DOI:10.1002/ijc.33806